Implications of incidentally discovered, nonfunctioning pancreatic endocrine tumors: Short-term and long-term patient outcomes

Alex B. Haynes, Vikram Deshpande, Thun Ingkakul, Parsia A. Vagefi, Jackie Szymonifka, Sarah P. Thayer, Cristina R. Ferrone, Jennifer A. Wargo, Andrew L. Warshaw, Carlos Fernández Del Castillo

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Abstract

Objectives: To describe the characteristics and outcomes after resection of incidentally discovered, nonfunctioning pancreatic endocrine tumors (PETs). Design: Case series. Setting: Academic hospital. Patients: Consecutive patients with an incidentally identified, nonfunctioning PET resected from May 1, 1977, through July 31, 2009. Main Outcome Measures: Operative morbidity and survival after resection. Results: A total of 139 patients with median age of 56 years (range, 21-85 years) underwent resection; tumor size ranged from 0.4 to 17.0 cm, with median size of 3.0 cm. No perioperative deaths were reported. Sixty-one patients (43.9%) experienced a perioperative complication. Twenty-six tumors (18.7%) were classified as benign, 39 (28.1%) as malignant, and 72 (51.8%) as uncertain. We were unable to confidently classify 2 tumors due to lack of information regarding mitotic rate in the pathology report. Complete follow-up was available for 112 patients (80.6%) (median, 34.2 months). Five-year actuarial survival rates were 88.8% for patients with benign disease, 92.5% for patients with tumors of uncertain biology, and 49.8% for those with malignant tumors (P=.01). Late metastasis, tumor recurrence, or disease progression were seen in 1 patient (3.8%) with tumors initially classified as benign, 8 patients (11.1%) with uncertain tumors, and 15 patients (38.5%) with tumors classified as malignant (P<.001). Of the 39 patients with tumors 2 cm or smaller, 3 (7.7%) had late metastases or recurrence. When compared with patients with symptomatic, nonfunctioning PETs, no large difference was observed in tumor size, patient age, disease, or survival. Conclusions: Incidentally detected, nonfunctioning PETs can display aggressive behavior, even when small. Although patients with malignant disease had diminished survival and increased rates of recurrence, benign histologic findings did not eliminate the possibility of progression. Patients with incidentally discovered, nonfunctioning PETs should undergo tumor resection and careful postoperative surveillance, even if surgical pathologic findings suggest benign disease.

Original languageEnglish (US)
Pages (from-to)534-538
Number of pages5
JournalArchives of Surgery
Volume146
Issue number5
DOIs
StatePublished - May 1 2011

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Neoplasms
Recurrence
Survival Rate
Neoplasm Metastasis
Survival
Disease Progression
Outcome Assessment (Health Care)
Pathology
Morbidity

ASJC Scopus subject areas

  • Surgery

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Implications of incidentally discovered, nonfunctioning pancreatic endocrine tumors : Short-term and long-term patient outcomes. / Haynes, Alex B.; Deshpande, Vikram; Ingkakul, Thun; Vagefi, Parsia A.; Szymonifka, Jackie; Thayer, Sarah P.; Ferrone, Cristina R.; Wargo, Jennifer A.; Warshaw, Andrew L.; Castillo, Carlos Fernández Del.

In: Archives of Surgery, Vol. 146, No. 5, 01.05.2011, p. 534-538.

Research output: Contribution to journalArticle

Haynes, AB, Deshpande, V, Ingkakul, T, Vagefi, PA, Szymonifka, J, Thayer, SP, Ferrone, CR, Wargo, JA, Warshaw, AL & Castillo, CFD 2011, 'Implications of incidentally discovered, nonfunctioning pancreatic endocrine tumors: Short-term and long-term patient outcomes', Archives of Surgery, vol. 146, no. 5, pp. 534-538. https://doi.org/10.1001/archsurg.2011.102
Haynes, Alex B. ; Deshpande, Vikram ; Ingkakul, Thun ; Vagefi, Parsia A. ; Szymonifka, Jackie ; Thayer, Sarah P. ; Ferrone, Cristina R. ; Wargo, Jennifer A. ; Warshaw, Andrew L. ; Castillo, Carlos Fernández Del. / Implications of incidentally discovered, nonfunctioning pancreatic endocrine tumors : Short-term and long-term patient outcomes. In: Archives of Surgery. 2011 ; Vol. 146, No. 5. pp. 534-538.
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title = "Implications of incidentally discovered, nonfunctioning pancreatic endocrine tumors: Short-term and long-term patient outcomes",
abstract = "Objectives: To describe the characteristics and outcomes after resection of incidentally discovered, nonfunctioning pancreatic endocrine tumors (PETs). Design: Case series. Setting: Academic hospital. Patients: Consecutive patients with an incidentally identified, nonfunctioning PET resected from May 1, 1977, through July 31, 2009. Main Outcome Measures: Operative morbidity and survival after resection. Results: A total of 139 patients with median age of 56 years (range, 21-85 years) underwent resection; tumor size ranged from 0.4 to 17.0 cm, with median size of 3.0 cm. No perioperative deaths were reported. Sixty-one patients (43.9{\%}) experienced a perioperative complication. Twenty-six tumors (18.7{\%}) were classified as benign, 39 (28.1{\%}) as malignant, and 72 (51.8{\%}) as uncertain. We were unable to confidently classify 2 tumors due to lack of information regarding mitotic rate in the pathology report. Complete follow-up was available for 112 patients (80.6{\%}) (median, 34.2 months). Five-year actuarial survival rates were 88.8{\%} for patients with benign disease, 92.5{\%} for patients with tumors of uncertain biology, and 49.8{\%} for those with malignant tumors (P=.01). Late metastasis, tumor recurrence, or disease progression were seen in 1 patient (3.8{\%}) with tumors initially classified as benign, 8 patients (11.1{\%}) with uncertain tumors, and 15 patients (38.5{\%}) with tumors classified as malignant (P<.001). Of the 39 patients with tumors 2 cm or smaller, 3 (7.7{\%}) had late metastases or recurrence. When compared with patients with symptomatic, nonfunctioning PETs, no large difference was observed in tumor size, patient age, disease, or survival. Conclusions: Incidentally detected, nonfunctioning PETs can display aggressive behavior, even when small. Although patients with malignant disease had diminished survival and increased rates of recurrence, benign histologic findings did not eliminate the possibility of progression. Patients with incidentally discovered, nonfunctioning PETs should undergo tumor resection and careful postoperative surveillance, even if surgical pathologic findings suggest benign disease.",
author = "Haynes, {Alex B.} and Vikram Deshpande and Thun Ingkakul and Vagefi, {Parsia A.} and Jackie Szymonifka and Thayer, {Sarah P.} and Ferrone, {Cristina R.} and Wargo, {Jennifer A.} and Warshaw, {Andrew L.} and Castillo, {Carlos Fern{\'a}ndez Del}",
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AU - Haynes, Alex B.

AU - Deshpande, Vikram

AU - Ingkakul, Thun

AU - Vagefi, Parsia A.

AU - Szymonifka, Jackie

AU - Thayer, Sarah P.

AU - Ferrone, Cristina R.

AU - Wargo, Jennifer A.

AU - Warshaw, Andrew L.

AU - Castillo, Carlos Fernández Del

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N2 - Objectives: To describe the characteristics and outcomes after resection of incidentally discovered, nonfunctioning pancreatic endocrine tumors (PETs). Design: Case series. Setting: Academic hospital. Patients: Consecutive patients with an incidentally identified, nonfunctioning PET resected from May 1, 1977, through July 31, 2009. Main Outcome Measures: Operative morbidity and survival after resection. Results: A total of 139 patients with median age of 56 years (range, 21-85 years) underwent resection; tumor size ranged from 0.4 to 17.0 cm, with median size of 3.0 cm. No perioperative deaths were reported. Sixty-one patients (43.9%) experienced a perioperative complication. Twenty-six tumors (18.7%) were classified as benign, 39 (28.1%) as malignant, and 72 (51.8%) as uncertain. We were unable to confidently classify 2 tumors due to lack of information regarding mitotic rate in the pathology report. Complete follow-up was available for 112 patients (80.6%) (median, 34.2 months). Five-year actuarial survival rates were 88.8% for patients with benign disease, 92.5% for patients with tumors of uncertain biology, and 49.8% for those with malignant tumors (P=.01). Late metastasis, tumor recurrence, or disease progression were seen in 1 patient (3.8%) with tumors initially classified as benign, 8 patients (11.1%) with uncertain tumors, and 15 patients (38.5%) with tumors classified as malignant (P<.001). Of the 39 patients with tumors 2 cm or smaller, 3 (7.7%) had late metastases or recurrence. When compared with patients with symptomatic, nonfunctioning PETs, no large difference was observed in tumor size, patient age, disease, or survival. Conclusions: Incidentally detected, nonfunctioning PETs can display aggressive behavior, even when small. Although patients with malignant disease had diminished survival and increased rates of recurrence, benign histologic findings did not eliminate the possibility of progression. Patients with incidentally discovered, nonfunctioning PETs should undergo tumor resection and careful postoperative surveillance, even if surgical pathologic findings suggest benign disease.

AB - Objectives: To describe the characteristics and outcomes after resection of incidentally discovered, nonfunctioning pancreatic endocrine tumors (PETs). Design: Case series. Setting: Academic hospital. Patients: Consecutive patients with an incidentally identified, nonfunctioning PET resected from May 1, 1977, through July 31, 2009. Main Outcome Measures: Operative morbidity and survival after resection. Results: A total of 139 patients with median age of 56 years (range, 21-85 years) underwent resection; tumor size ranged from 0.4 to 17.0 cm, with median size of 3.0 cm. No perioperative deaths were reported. Sixty-one patients (43.9%) experienced a perioperative complication. Twenty-six tumors (18.7%) were classified as benign, 39 (28.1%) as malignant, and 72 (51.8%) as uncertain. We were unable to confidently classify 2 tumors due to lack of information regarding mitotic rate in the pathology report. Complete follow-up was available for 112 patients (80.6%) (median, 34.2 months). Five-year actuarial survival rates were 88.8% for patients with benign disease, 92.5% for patients with tumors of uncertain biology, and 49.8% for those with malignant tumors (P=.01). Late metastasis, tumor recurrence, or disease progression were seen in 1 patient (3.8%) with tumors initially classified as benign, 8 patients (11.1%) with uncertain tumors, and 15 patients (38.5%) with tumors classified as malignant (P<.001). Of the 39 patients with tumors 2 cm or smaller, 3 (7.7%) had late metastases or recurrence. When compared with patients with symptomatic, nonfunctioning PETs, no large difference was observed in tumor size, patient age, disease, or survival. Conclusions: Incidentally detected, nonfunctioning PETs can display aggressive behavior, even when small. Although patients with malignant disease had diminished survival and increased rates of recurrence, benign histologic findings did not eliminate the possibility of progression. Patients with incidentally discovered, nonfunctioning PETs should undergo tumor resection and careful postoperative surveillance, even if surgical pathologic findings suggest benign disease.

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