Implementation and performance of the BioFire FilmArray® Blood Culture Identification panel with antimicrobial treatment recommendations for bloodstream infections at a midwestern academic tertiary hospital

Timothy R. Southern, Trevor C VanSchooneveld, Dianna L. Bannister, TeAnne L. Brown, Amy S. Crismon, Sarah N. Buss, Peter Charles Iwen, Paul D Fey

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The FilmArray® Blood Culture Identification (BCID) panel was recently implemented at a midwestern academic tertiary care hospital to provide rapid identification (ID) of common pathogens from positive blood cultures. This study evaluated the clinical performance of the BCID panel compared to culture-based ID methods. One hundred thirty-eight monomicrobial and 8 polymicrobial blood cultures were evaluated during the 30-day study resulting in the ID of 152 total organisms by culture with 115 organisms correctly identified using the BCID panel. The BCID panel had sensitivities of 80.4% (115/152) for all organisms identified during the study and 94.6% (115/122) when considering only on-panel organisms. BCID panel specificity was 100%. Implementation of the BCID panel was coupled with the development of empiric therapy recommendations for bloodstream infections by the antimicrobial stewardship team. Based on this study, the FilmArray® BCID panel is a rapid and reliable test for the detection of common bloodstream pathogens, and therapeutic decisions can be based upon panel results.

Original languageEnglish (US)
Pages (from-to)96-101
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume81
Issue number2
DOIs
StatePublished - Jan 1 2015

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Tertiary Care Centers
Infection
Blood Culture
Tertiary Healthcare
Therapeutics

Keywords

  • Antimicrobial recommendations
  • Antimicrobial stewardship
  • BCID
  • Bloodstream infection
  • Clinical performance
  • FilmArray Blood Culture Identification panel

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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abstract = "The FilmArray{\circledR} Blood Culture Identification (BCID) panel was recently implemented at a midwestern academic tertiary care hospital to provide rapid identification (ID) of common pathogens from positive blood cultures. This study evaluated the clinical performance of the BCID panel compared to culture-based ID methods. One hundred thirty-eight monomicrobial and 8 polymicrobial blood cultures were evaluated during the 30-day study resulting in the ID of 152 total organisms by culture with 115 organisms correctly identified using the BCID panel. The BCID panel had sensitivities of 80.4{\%} (115/152) for all organisms identified during the study and 94.6{\%} (115/122) when considering only on-panel organisms. BCID panel specificity was 100{\%}. Implementation of the BCID panel was coupled with the development of empiric therapy recommendations for bloodstream infections by the antimicrobial stewardship team. Based on this study, the FilmArray{\circledR} BCID panel is a rapid and reliable test for the detection of common bloodstream pathogens, and therapeutic decisions can be based upon panel results.",
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AU - Crismon, Amy S.

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