Implantation of left ventricular assist device

Complicated by undiagnosed thrombophilia

Ondrej Szarszoi, Jiri Maly, Daniel Turek, Marian Urban, Ivo Skalsky, Hynek Riha, Jana Maluskova, Jan Pirk, Ivan Netuka

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A patient with dilated cardiomyopathy and no history of thromboembolic events received a surgically implanted axial-flow left ventricular assist device. After implantation, transesophageal echocardiography revealed a giant thrombus on the lateral and anterior aspects of the left ventricle. The inflow cannula inserted through the apex of the left ventricle was not obstructed, and the device generated satisfactory blood flow. Laboratory screening for thrombophilia showed protein S deficiency, heterozygous factor V Leiden mutation, and heterozygous MTHFR C667T mutation. During the entire duration of circulatory support, no significant suction events were detected, and the patient was listed for heart transplantation. Ventricular assist device implantation can unmask previously undiagnosed thrombophilia; therefore, it should be necessary to identify thrombophilic patients before cardiac support implantation.

Original languageEnglish (US)
Pages (from-to)615-617
Number of pages3
JournalTexas Heart Institute Journal
Volume39
Issue number5
StatePublished - Oct 1 2012

Fingerprint

Heart-Assist Devices
Thrombophilia
Heart Ventricles
Protein S Deficiency
Mutation
Transesophageal Echocardiography
Suction
Dilated Cardiomyopathy
Heart Transplantation
Thrombosis
Equipment and Supplies

Keywords

  • Anticoagulants/therapeutic use
  • Blood coagulation disorders/complications
  • Factor V Leiden
  • Factor V/genetics
  • Left ventricular assist device
  • Perioperative care
  • Postoperative complications
  • Thrombophilia/genetics
  • Thrombus/etiology/ prevention & control

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Szarszoi, O., Maly, J., Turek, D., Urban, M., Skalsky, I., Riha, H., ... Netuka, I. (2012). Implantation of left ventricular assist device: Complicated by undiagnosed thrombophilia. Texas Heart Institute Journal, 39(5), 615-617.

Implantation of left ventricular assist device : Complicated by undiagnosed thrombophilia. / Szarszoi, Ondrej; Maly, Jiri; Turek, Daniel; Urban, Marian; Skalsky, Ivo; Riha, Hynek; Maluskova, Jana; Pirk, Jan; Netuka, Ivan.

In: Texas Heart Institute Journal, Vol. 39, No. 5, 01.10.2012, p. 615-617.

Research output: Contribution to journalArticle

Szarszoi, O, Maly, J, Turek, D, Urban, M, Skalsky, I, Riha, H, Maluskova, J, Pirk, J & Netuka, I 2012, 'Implantation of left ventricular assist device: Complicated by undiagnosed thrombophilia', Texas Heart Institute Journal, vol. 39, no. 5, pp. 615-617.
Szarszoi, Ondrej ; Maly, Jiri ; Turek, Daniel ; Urban, Marian ; Skalsky, Ivo ; Riha, Hynek ; Maluskova, Jana ; Pirk, Jan ; Netuka, Ivan. / Implantation of left ventricular assist device : Complicated by undiagnosed thrombophilia. In: Texas Heart Institute Journal. 2012 ; Vol. 39, No. 5. pp. 615-617.
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