Impairment of melibiose utilization in Streptococcus mutans serotype c gtfA mutants

Raul G Barletta, R. Curtiss

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The Streptococcus mutans serotype c gtfA gene encodes a 55-kilodalton sucrose-hydrolyzing enzyme. Analysis of S. mutans gtfA mutants revealed that the mutant strains were specifically impaired in the ability to use melibiose as a sole carbon source. S. mutans gtfA mutant strains synthesized less α-galactosidase activity inducible by raffinose than wild-type strains. Melibiose (an inducer in wild-type strains) failed to induce significant levels of α-galactosidase in the mutant strains. We hypothesize that melibiose use by S. mutans requires the interaction of the GtfA enzyme, or another gene product under the control of the gtfA promoter, with other gene product(s) involved in melibiose transport or hydrolysis.

Original languageEnglish (US)
Pages (from-to)992-995
Number of pages4
JournalInfection and Immunity
Volume57
Issue number3
StatePublished - Jan 1 1989

Fingerprint

Melibiose
Streptococcus mutans
Galactosidases
Genes
Raffinose
Enzymes
Sucrose
Hydrolysis
Carbon
Serogroup

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Impairment of melibiose utilization in Streptococcus mutans serotype c gtfA mutants. / Barletta, Raul G; Curtiss, R.

In: Infection and Immunity, Vol. 57, No. 3, 01.01.1989, p. 992-995.

Research output: Contribution to journalArticle

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