Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders

Pierluca Coiro, Ragunathan Padmashri, Anand Suresh, Elizabeth Spartz, Gurudutt N Pendyala, Shinnyi Chou, Yoosun Jung, Brittney Meays, Shreya Roy, Nagsen Gautam, Yazen Alnouti, Ming Li, Anna Dunaevsky-Hutt

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Both genetic and environmental factors are thought to contribute to neurodevelopmental and neuropsychiatric disorders with maternal immune activation (MIA) being a risk factor for both autism spectrum disorders and schizophrenia. Although MIA mouse offspring exhibit behavioral impairments, the synaptic alterations in vivo that mediate these behaviors are not known. Here we employed in vivo multiphoton imaging to determine that in the cortex of young MIA offspring there is a reduction in number and turnover rates of dendritic spines, sites of majority of excitatory synaptic inputs. Significantly, spine impairments persisted into adulthood and correlated with increased repetitive behavior, an ASD relevant behavioral phenotype. Structural analysis of synaptic inputs revealed a reorganization of presynaptic inputs with a larger proportion of spines being contacted by both excitatory and inhibitory presynaptic terminals. These structural impairments were accompanied by altered excitatory and inhibitory synaptic transmission. Finally, we report that a postnatal treatment of MIA offspring with the anti-inflammatory drug ibudilast, prevented both synaptic and behavioral impairments. Our results suggest that a possible altered inflammatory state associated with maternal immune activation results in impaired synaptic development that persists into adulthood but which can be prevented with early anti-inflammatory treatment.

Original languageEnglish (US)
Pages (from-to)249-258
Number of pages10
JournalBrain, Behavior, and Immunity
Volume50
DOIs
StatePublished - Nov 1 2015

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Mothers
Spine
Anti-Inflammatory Agents
Dendritic Spines
Presynaptic Terminals
Synaptic Transmission
Schizophrenia
Neurodevelopmental Disorders
Phenotype
Pharmaceutical Preparations

Keywords

  • Anti-inflammatory
  • Autism
  • Dendritic spines
  • Excitation
  • Inflammation
  • Inhibition

ASJC Scopus subject areas

  • Immunology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

Cite this

Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders. / Coiro, Pierluca; Padmashri, Ragunathan; Suresh, Anand; Spartz, Elizabeth; Pendyala, Gurudutt N; Chou, Shinnyi; Jung, Yoosun; Meays, Brittney; Roy, Shreya; Gautam, Nagsen; Alnouti, Yazen; Li, Ming; Dunaevsky-Hutt, Anna.

In: Brain, Behavior, and Immunity, Vol. 50, 01.11.2015, p. 249-258.

Research output: Contribution to journalArticle

Coiro, Pierluca ; Padmashri, Ragunathan ; Suresh, Anand ; Spartz, Elizabeth ; Pendyala, Gurudutt N ; Chou, Shinnyi ; Jung, Yoosun ; Meays, Brittney ; Roy, Shreya ; Gautam, Nagsen ; Alnouti, Yazen ; Li, Ming ; Dunaevsky-Hutt, Anna. / Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders. In: Brain, Behavior, and Immunity. 2015 ; Vol. 50. pp. 249-258.
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