Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion

Abigail A. Marsh, Elizabeth C. Finger, Beata Buzas, Niveen Soliman, Rebecca A. Richell, Meena Vythilingham, Daniel S. Pine, David Goldman, Robert James Blair

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Rationale: Genotype at the 5′ promoter region (5-HTTLPR) of the serotonin transporter has been implicated in moderating the effects of acute tryptophan depletion on neurocognitive functioning. Acute tryptophan depletion has been associated with the processing of fear-relevant cues, such as emotional expressions, but the effect of genotype at the 5-HTTLPR has not been assessed. Objective: The present study investigated the effects of acute tryptophan depletion on the recognition of standardized facial expressions of emotions in healthy volunteers classified as ll homozygotes or s carriers. Materials and methods: A double-blind between-groups design was used with volunteers randomly selected to ingest capsules containing an amino acid mixture specifically lacking tryptophan, or placebo capsules containing lactose. 5 h after capsule ingestion, subjects were required to identify anger, disgust, fear, happiness, sadness, and surprise expressions that progressed from neutral to each full emotional expression in 5% steps. Results: Tryptophan depletion significantly impaired the recognition of fearful facial expressions in s carriers but not ll homozygotes. This impairment was specific to fear expressions. No significant differences in the recognition of other expressions were found. Free tryptophan levels were correlated with fear recognition in s carriers but not ll homozygotes. Conclusions: The effects of acute tryptophan depletion on the processing of emotional expressions varies as a function of genotype at the 5-HTTLPR. Depletion impairs the recognition of fear in s carriers but not ll homozygotes. This finding reinforces the importance of considering genotype when assessing the behavioral effects of pharmacologic modulation.

Original languageEnglish (US)
Pages (from-to)387-394
Number of pages8
JournalPsychopharmacology
Volume189
Issue number3
DOIs
StatePublished - Dec 1 2006

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Facial Expression
Tryptophan
Fear
Homozygote
Genotype
Capsules
Serotonin Plasma Membrane Transport Proteins
Happiness
Anger
Lactose
Recognition (Psychology)
Double-Blind Method
Genetic Promoter Regions
Cues
Volunteers
Healthy Volunteers
Emotions
Eating
Placebos
Amino Acids

Keywords

  • 5-HTTLPR
  • Amygdala
  • Fear
  • Serotonin
  • Tryptophan depletion

ASJC Scopus subject areas

  • Pharmacology

Cite this

Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion. / Marsh, Abigail A.; Finger, Elizabeth C.; Buzas, Beata; Soliman, Niveen; Richell, Rebecca A.; Vythilingham, Meena; Pine, Daniel S.; Goldman, David; Blair, Robert James.

In: Psychopharmacology, Vol. 189, No. 3, 01.12.2006, p. 387-394.

Research output: Contribution to journalArticle

Marsh, AA, Finger, EC, Buzas, B, Soliman, N, Richell, RA, Vythilingham, M, Pine, DS, Goldman, D & Blair, RJ 2006, 'Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion', Psychopharmacology, vol. 189, no. 3, pp. 387-394. https://doi.org/10.1007/s00213-006-0581-2
Marsh, Abigail A. ; Finger, Elizabeth C. ; Buzas, Beata ; Soliman, Niveen ; Richell, Rebecca A. ; Vythilingham, Meena ; Pine, Daniel S. ; Goldman, David ; Blair, Robert James. / Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion. In: Psychopharmacology. 2006 ; Vol. 189, No. 3. pp. 387-394.
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AU - Richell, Rebecca A.

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AU - Pine, Daniel S.

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N2 - Rationale: Genotype at the 5′ promoter region (5-HTTLPR) of the serotonin transporter has been implicated in moderating the effects of acute tryptophan depletion on neurocognitive functioning. Acute tryptophan depletion has been associated with the processing of fear-relevant cues, such as emotional expressions, but the effect of genotype at the 5-HTTLPR has not been assessed. Objective: The present study investigated the effects of acute tryptophan depletion on the recognition of standardized facial expressions of emotions in healthy volunteers classified as ll homozygotes or s carriers. Materials and methods: A double-blind between-groups design was used with volunteers randomly selected to ingest capsules containing an amino acid mixture specifically lacking tryptophan, or placebo capsules containing lactose. 5 h after capsule ingestion, subjects were required to identify anger, disgust, fear, happiness, sadness, and surprise expressions that progressed from neutral to each full emotional expression in 5% steps. Results: Tryptophan depletion significantly impaired the recognition of fearful facial expressions in s carriers but not ll homozygotes. This impairment was specific to fear expressions. No significant differences in the recognition of other expressions were found. Free tryptophan levels were correlated with fear recognition in s carriers but not ll homozygotes. Conclusions: The effects of acute tryptophan depletion on the processing of emotional expressions varies as a function of genotype at the 5-HTTLPR. Depletion impairs the recognition of fear in s carriers but not ll homozygotes. This finding reinforces the importance of considering genotype when assessing the behavioral effects of pharmacologic modulation.

AB - Rationale: Genotype at the 5′ promoter region (5-HTTLPR) of the serotonin transporter has been implicated in moderating the effects of acute tryptophan depletion on neurocognitive functioning. Acute tryptophan depletion has been associated with the processing of fear-relevant cues, such as emotional expressions, but the effect of genotype at the 5-HTTLPR has not been assessed. Objective: The present study investigated the effects of acute tryptophan depletion on the recognition of standardized facial expressions of emotions in healthy volunteers classified as ll homozygotes or s carriers. Materials and methods: A double-blind between-groups design was used with volunteers randomly selected to ingest capsules containing an amino acid mixture specifically lacking tryptophan, or placebo capsules containing lactose. 5 h after capsule ingestion, subjects were required to identify anger, disgust, fear, happiness, sadness, and surprise expressions that progressed from neutral to each full emotional expression in 5% steps. Results: Tryptophan depletion significantly impaired the recognition of fearful facial expressions in s carriers but not ll homozygotes. This impairment was specific to fear expressions. No significant differences in the recognition of other expressions were found. Free tryptophan levels were correlated with fear recognition in s carriers but not ll homozygotes. Conclusions: The effects of acute tryptophan depletion on the processing of emotional expressions varies as a function of genotype at the 5-HTTLPR. Depletion impairs the recognition of fear in s carriers but not ll homozygotes. This finding reinforces the importance of considering genotype when assessing the behavioral effects of pharmacologic modulation.

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