Impaired Performance on a Rhesus Monkey Neuropsychological Testing Battery following Simian Immunodeficiency Virus Infection

Michael R. Weed, Lisa H. Gold, Ilham Polis, George F. Koob, Howard S. Fox, Michael A. Taffe

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Infection with simian immunodeficiency virus (SIV) in macaques provides an excellent model of AIDS including HIV-induced central nervous system (CNS) pathology and cognitive/behavioral impairment. Recently a behavioral test battery has been developed for macaques based on the CANTAB human neuropsychological testing battery. As with human neuropsychological batteries, different tasks are thought to involve different neural substrates, and therefore performance profiles may assess function in particular brain regions. Ten rhesus monkeys were infected with SIV after being trained on two or more of the battery tasks addressing memory (delayed nonmatching to sample, DNMS), spatial working memory (using a self-ordered spatial search task, SOSS), motivation (progressive-ratio, PR), reaction time (RT), and/or fine motor skills (bimanual motor skill, BMS). Performance was compared to that of 9 uninfected monkeys. Overall, some aspect of performance was impaired in all 10 monkeys following infection. Consistent with results in human AIDS patients, individual performance was impaired most often on battery tasks thought to be sensitive to frontostriatal dopaminergic functioning such as SOSS, RT, and BMS. These results further demonstrate the similarity of behavioral impairment produced by SIV and HIV on homologous behavioral tests, and establish the utility of the testing battery for further investigations into the CNS mechanisms of the reported behavioral changes.

Original languageEnglish (US)
Pages (from-to)77-89
Number of pages13
JournalAIDS Research and Human Retroviruses
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2004

Fingerprint

Simian Immunodeficiency Virus
Motor Skills
Virus Diseases
Macaca mulatta
Macaca
Reaction Time
Haplorhini
Acquired Immunodeficiency Syndrome
Central Nervous System
HIV
Repression (Psychology)
Infection
Short-Term Memory
Motivation
Pathology
Brain
Behavior Rating Scale

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Impaired Performance on a Rhesus Monkey Neuropsychological Testing Battery following Simian Immunodeficiency Virus Infection. / Weed, Michael R.; Gold, Lisa H.; Polis, Ilham; Koob, George F.; Fox, Howard S.; Taffe, Michael A.

In: AIDS Research and Human Retroviruses, Vol. 20, No. 1, 01.01.2004, p. 77-89.

Research output: Contribution to journalArticle

Weed, Michael R. ; Gold, Lisa H. ; Polis, Ilham ; Koob, George F. ; Fox, Howard S. ; Taffe, Michael A. / Impaired Performance on a Rhesus Monkey Neuropsychological Testing Battery following Simian Immunodeficiency Virus Infection. In: AIDS Research and Human Retroviruses. 2004 ; Vol. 20, No. 1. pp. 77-89.
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