Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination

Nishaki Mehta, Coleen K. Cunningham, Patricia Flynn, Joyce Pepe, Stephen Obaro, Bill G. Kapogiannis, James Bethel, Katherine Luzuriaga

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10 mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000 mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.

Original languageEnglish (US)
Pages (from-to)3672-3678
Number of pages7
JournalVaccine
Volume28
Issue number21
DOIs
StatePublished - May 7 2010

Fingerprint

Hepatitis B virus
hepatitis B
B-lymphocytes
Vaccination
B-Lymphocytes
Hepatitis B
vaccination
HIV
cell proliferation
phenotype
Cell Proliferation
antibodies
Phenotype
Antibodies

Keywords

  • HIV
  • Hepatitis B vaccines
  • Memory B cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Mehta, N., Cunningham, C. K., Flynn, P., Pepe, J., Obaro, S., Kapogiannis, B. G., ... Luzuriaga, K. (2010). Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination. Vaccine, 28(21), 3672-3678. https://doi.org/10.1016/j.vaccine.2010.03.022

Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination. / Mehta, Nishaki; Cunningham, Coleen K.; Flynn, Patricia; Pepe, Joyce; Obaro, Stephen; Kapogiannis, Bill G.; Bethel, James; Luzuriaga, Katherine.

In: Vaccine, Vol. 28, No. 21, 07.05.2010, p. 3672-3678.

Research output: Contribution to journalArticle

Mehta, N, Cunningham, CK, Flynn, P, Pepe, J, Obaro, S, Kapogiannis, BG, Bethel, J & Luzuriaga, K 2010, 'Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination', Vaccine, vol. 28, no. 21, pp. 3672-3678. https://doi.org/10.1016/j.vaccine.2010.03.022
Mehta, Nishaki ; Cunningham, Coleen K. ; Flynn, Patricia ; Pepe, Joyce ; Obaro, Stephen ; Kapogiannis, Bill G. ; Bethel, James ; Luzuriaga, Katherine. / Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination. In: Vaccine. 2010 ; Vol. 28, No. 21. pp. 3672-3678.
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