Impaired fixation to eyes during facial emotion labelling in children with bipolar disorder or severe mood dysregulation

Pilyoung Kim, Joseph Arizpe, Brooke H. Rosen, Varun Razdan, Catherine T. Haring, Sarah E. Jenkins, Christen M. Deveney, Melissa A. Brotman, Robert James Blair, Daniel S. Pine, Chris I. Baker, Ellen Leibenluft

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Children with bipolar disorder (BD) or severe mood dysregulation (SMD) show behavioural and neural deficits during facial emotion processing. In those with other psychiatric disorders, such deficits have been associated with reduced attention to eye regions while looking at faces. Methods: We examined gaze fixation patterns during a facial emotion labelling task among children with pediatric BD and SMD and among healthy controls. Participants viewed facial expressions with varying emotions (anger, fear, sadness, happiness, neutral) and emotional levels (60%, 80%, 100%) and labelled emotional expressions. Results: Our study included 22 children with BD, 28 with SMD and 22 controls. Across all facial emotions, children with BD and SMD made more labelling errors than controls. Compared with controls, children with BD spent less time looking at eyes and made fewer eye fixations across emotional expressions. Gaze patterns in children with SMD tended to fall between those of children with BD and controls, although they did not differ significantly from either of these groups on most measures. Decreased fixations to eyes correlated with lower labelling accuracy in children with BD, but not in those with SMD or in controls. Limitations: Most children with BD were medicated, which precluded our ability to evaluate medication effects on gaze patterns. Conclusion: Facial emotion labelling deficits in children with BD are associated with impaired attention to eyes. Future research should examine whether impaired attention to eyes is associated with neural dysfunction. Eye gaze deficits in children with BD during facial emotion labelling may also have treatment implications. Finally, children with SMD exhibited decreased attention to eyes to a lesser extent than those with BD, and these equivocal findings are worthy of further study.

Original languageEnglish (US)
Pages (from-to)407-416
Number of pages10
JournalJournal of Psychiatry and Neuroscience
Volume38
Issue number6
DOIs
StatePublished - Jan 1 2013

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Bipolar Disorder
Emotions
Happiness
Facial Expression
Aptitude
Anger
Fear
Psychiatry
Pediatrics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

Cite this

Impaired fixation to eyes during facial emotion labelling in children with bipolar disorder or severe mood dysregulation. / Kim, Pilyoung; Arizpe, Joseph; Rosen, Brooke H.; Razdan, Varun; Haring, Catherine T.; Jenkins, Sarah E.; Deveney, Christen M.; Brotman, Melissa A.; Blair, Robert James; Pine, Daniel S.; Baker, Chris I.; Leibenluft, Ellen.

In: Journal of Psychiatry and Neuroscience, Vol. 38, No. 6, 01.01.2013, p. 407-416.

Research output: Contribution to journalArticle

Kim, P, Arizpe, J, Rosen, BH, Razdan, V, Haring, CT, Jenkins, SE, Deveney, CM, Brotman, MA, Blair, RJ, Pine, DS, Baker, CI & Leibenluft, E 2013, 'Impaired fixation to eyes during facial emotion labelling in children with bipolar disorder or severe mood dysregulation', Journal of Psychiatry and Neuroscience, vol. 38, no. 6, pp. 407-416. https://doi.org/10.1503/jpn.120232
Kim, Pilyoung ; Arizpe, Joseph ; Rosen, Brooke H. ; Razdan, Varun ; Haring, Catherine T. ; Jenkins, Sarah E. ; Deveney, Christen M. ; Brotman, Melissa A. ; Blair, Robert James ; Pine, Daniel S. ; Baker, Chris I. ; Leibenluft, Ellen. / Impaired fixation to eyes during facial emotion labelling in children with bipolar disorder or severe mood dysregulation. In: Journal of Psychiatry and Neuroscience. 2013 ; Vol. 38, No. 6. pp. 407-416.
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abstract = "Background: Children with bipolar disorder (BD) or severe mood dysregulation (SMD) show behavioural and neural deficits during facial emotion processing. In those with other psychiatric disorders, such deficits have been associated with reduced attention to eye regions while looking at faces. Methods: We examined gaze fixation patterns during a facial emotion labelling task among children with pediatric BD and SMD and among healthy controls. Participants viewed facial expressions with varying emotions (anger, fear, sadness, happiness, neutral) and emotional levels (60{\%}, 80{\%}, 100{\%}) and labelled emotional expressions. Results: Our study included 22 children with BD, 28 with SMD and 22 controls. Across all facial emotions, children with BD and SMD made more labelling errors than controls. Compared with controls, children with BD spent less time looking at eyes and made fewer eye fixations across emotional expressions. Gaze patterns in children with SMD tended to fall between those of children with BD and controls, although they did not differ significantly from either of these groups on most measures. Decreased fixations to eyes correlated with lower labelling accuracy in children with BD, but not in those with SMD or in controls. Limitations: Most children with BD were medicated, which precluded our ability to evaluate medication effects on gaze patterns. Conclusion: Facial emotion labelling deficits in children with BD are associated with impaired attention to eyes. Future research should examine whether impaired attention to eyes is associated with neural dysfunction. Eye gaze deficits in children with BD during facial emotion labelling may also have treatment implications. Finally, children with SMD exhibited decreased attention to eyes to a lesser extent than those with BD, and these equivocal findings are worthy of further study.",
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AU - Arizpe, Joseph

AU - Rosen, Brooke H.

AU - Razdan, Varun

AU - Haring, Catherine T.

AU - Jenkins, Sarah E.

AU - Deveney, Christen M.

AU - Brotman, Melissa A.

AU - Blair, Robert James

AU - Pine, Daniel S.

AU - Baker, Chris I.

AU - Leibenluft, Ellen

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N2 - Background: Children with bipolar disorder (BD) or severe mood dysregulation (SMD) show behavioural and neural deficits during facial emotion processing. In those with other psychiatric disorders, such deficits have been associated with reduced attention to eye regions while looking at faces. Methods: We examined gaze fixation patterns during a facial emotion labelling task among children with pediatric BD and SMD and among healthy controls. Participants viewed facial expressions with varying emotions (anger, fear, sadness, happiness, neutral) and emotional levels (60%, 80%, 100%) and labelled emotional expressions. Results: Our study included 22 children with BD, 28 with SMD and 22 controls. Across all facial emotions, children with BD and SMD made more labelling errors than controls. Compared with controls, children with BD spent less time looking at eyes and made fewer eye fixations across emotional expressions. Gaze patterns in children with SMD tended to fall between those of children with BD and controls, although they did not differ significantly from either of these groups on most measures. Decreased fixations to eyes correlated with lower labelling accuracy in children with BD, but not in those with SMD or in controls. Limitations: Most children with BD were medicated, which precluded our ability to evaluate medication effects on gaze patterns. Conclusion: Facial emotion labelling deficits in children with BD are associated with impaired attention to eyes. Future research should examine whether impaired attention to eyes is associated with neural dysfunction. Eye gaze deficits in children with BD during facial emotion labelling may also have treatment implications. Finally, children with SMD exhibited decreased attention to eyes to a lesser extent than those with BD, and these equivocal findings are worthy of further study.

AB - Background: Children with bipolar disorder (BD) or severe mood dysregulation (SMD) show behavioural and neural deficits during facial emotion processing. In those with other psychiatric disorders, such deficits have been associated with reduced attention to eye regions while looking at faces. Methods: We examined gaze fixation patterns during a facial emotion labelling task among children with pediatric BD and SMD and among healthy controls. Participants viewed facial expressions with varying emotions (anger, fear, sadness, happiness, neutral) and emotional levels (60%, 80%, 100%) and labelled emotional expressions. Results: Our study included 22 children with BD, 28 with SMD and 22 controls. Across all facial emotions, children with BD and SMD made more labelling errors than controls. Compared with controls, children with BD spent less time looking at eyes and made fewer eye fixations across emotional expressions. Gaze patterns in children with SMD tended to fall between those of children with BD and controls, although they did not differ significantly from either of these groups on most measures. Decreased fixations to eyes correlated with lower labelling accuracy in children with BD, but not in those with SMD or in controls. Limitations: Most children with BD were medicated, which precluded our ability to evaluate medication effects on gaze patterns. Conclusion: Facial emotion labelling deficits in children with BD are associated with impaired attention to eyes. Future research should examine whether impaired attention to eyes is associated with neural dysfunction. Eye gaze deficits in children with BD during facial emotion labelling may also have treatment implications. Finally, children with SMD exhibited decreased attention to eyes to a lesser extent than those with BD, and these equivocal findings are worthy of further study.

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