Impact of simultaneous pancreas and kidney transplantation on cardiovascular risk factors in patients with type 1 diabetes mellitus

Fu L. Luan, Clifford D. Miles, Diane M. Cibrik, Akinlolu O. Ojo

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

We retrospectively investigated the impact of pancreas transplantation on cardiovascular disease risk factors in patients with type 1 diabetic end-stage renal disease (ESRD). Two cohorts of patients, 44 simultaneous pancreas and kidney transplant patients (SPK) and 30 kidney transplant-alone patients (KTA), were included. Univariate and multivariate analyses were performed. Compared with KTA patients, SPK patients had significantly lower mean arterial pressure (88.5±12.7 vs. 98.2±13.0 mmHg, P=0.002), lower pulse pressure (51.6±15.1 vs. 61.4±15.6 mmHg, P=0.008), lower low-density lipoprotein cholesterol (83.5±20.6 vs. 99.2±32.5 mg/dl, P=0.02), and required fewer lipid-lowering medications (31.8% vs. 60.0%, P=0.02). Compared with pretransplant values, only SPK patients showed significant improvement in both blood pressure and total cholesterol. We conclude that SPK significantly improves blood pressure and dyslipidemia compared with KTA in type 1 diabetic ESRD patients.

Original languageEnglish (US)
Pages (from-to)541-544
Number of pages4
JournalTransplantation
Volume84
Issue number4
DOIs
StatePublished - Aug 1 2007

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Keywords

  • Blood pressure
  • Lipids
  • Pancreas and kidney transplant

ASJC Scopus subject areas

  • Transplantation

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