Impact of simultaneous pancreas and kidney transplantation on cardiovascular risk factors in patients with type 1 diabetes mellitus

Fu L. Luan, Clifford D. Miles, Diane M. Cibrik, Akinlolu O. Ojo

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We retrospectively investigated the impact of pancreas transplantation on cardiovascular disease risk factors in patients with type 1 diabetic end-stage renal disease (ESRD). Two cohorts of patients, 44 simultaneous pancreas and kidney transplant patients (SPK) and 30 kidney transplant-alone patients (KTA), were included. Univariate and multivariate analyses were performed. Compared with KTA patients, SPK patients had significantly lower mean arterial pressure (88.5±12.7 vs. 98.2±13.0 mmHg, P=0.002), lower pulse pressure (51.6±15.1 vs. 61.4±15.6 mmHg, P=0.008), lower low-density lipoprotein cholesterol (83.5±20.6 vs. 99.2±32.5 mg/dl, P=0.02), and required fewer lipid-lowering medications (31.8% vs. 60.0%, P=0.02). Compared with pretransplant values, only SPK patients showed significant improvement in both blood pressure and total cholesterol. We conclude that SPK significantly improves blood pressure and dyslipidemia compared with KTA in type 1 diabetic ESRD patients.

Original languageEnglish (US)
Pages (from-to)541-544
Number of pages4
JournalTransplantation
Volume84
Issue number4
DOIs
StatePublished - Aug 1 2007

Fingerprint

Pancreas Transplantation
Type 1 Diabetes Mellitus
Kidney Transplantation
Transplants
Kidney
Blood Pressure
Chronic Kidney Failure
Dyslipidemias
LDL Cholesterol
Pancreas
Arterial Pressure
Cardiovascular Diseases
Multivariate Analysis
Cholesterol
Lipids

Keywords

  • Blood pressure
  • Lipids
  • Pancreas and kidney transplant

ASJC Scopus subject areas

  • Transplantation

Cite this

Impact of simultaneous pancreas and kidney transplantation on cardiovascular risk factors in patients with type 1 diabetes mellitus. / Luan, Fu L.; Miles, Clifford D.; Cibrik, Diane M.; Ojo, Akinlolu O.

In: Transplantation, Vol. 84, No. 4, 01.08.2007, p. 541-544.

Research output: Contribution to journalArticle

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