Impact of persistent minimal residual disease post-consolidation therapy in children and adolescents with advanced Burkitt leukaemia: a Children's Oncology Group Pilot Study Report

Bruce Shiramizu, Stanton Goldman, Lynette Smith, Melissa Agsalda-Garcia, Paul Galardy, Sherrie L. Perkins, J. Kimble Frazer, Warren Sanger, James R. Anderson, Thomas G. Gross, Howard Weinstein, Lauren Harrison, Matthew J. Barth, Lara Mussolin, Mitchell S. Cairo

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Patient-specific primers from 10 children/adolescents with Burkitt leukaemia (BL) ± central nervous system disease who were treated with French-British-American/Lymphome Malins de Burkitt 96 C1 plus rituximab were developed from diagnostic blood/bone marrow. Minimal residual disease (MRD) was assessed by real-time polymerase chain reaction at the end of induction (EOI) and consolidation (EOC). Seventy per cent (7/10) and 71% (5/7) were MRD-positive at EOI and EOC, respectively, with no disease recurrences. MRD after induction and consolidation did not predict relapse and subsequent therapy appeared to eliminate MRD. Thus, assessing MRD at a later time point is warranted in future trials to determine its clinical significance.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalBritish Journal of Haematology
Volume170
Issue number3
DOIs
StatePublished - Jan 1 2015

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Keywords

  • central nervous system
  • children
  • leukaemia

ASJC Scopus subject areas

  • Hematology

Cite this

Shiramizu, B., Goldman, S., Smith, L., Agsalda-Garcia, M., Galardy, P., Perkins, S. L., Frazer, J. K., Sanger, W., Anderson, J. R., Gross, T. G., Weinstein, H., Harrison, L., Barth, M. J., Mussolin, L., & Cairo, M. S. (2015). Impact of persistent minimal residual disease post-consolidation therapy in children and adolescents with advanced Burkitt leukaemia: a Children's Oncology Group Pilot Study Report. British Journal of Haematology, 170(3), 367-371. https://doi.org/10.1111/bjh.13443