Impact of increased occlusal contact, interleukin-1 genotype, and periodontitis severity on gingival crevicular fluid IL-1β levels

Michael J. McDevitt, Carl M. Russell, Marian J. Schmid, Richard A Reinhardt

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: The study of occlusal therapy in humans with periodontitis is problematic due to potential irreversible bone loss in control subjects. The hypothesis of this pilot investigation was that increased interocclusal contact initiated by short-term occlusal splint disuse would increase tooth mobility and the bone-resorptive cytokine interleukin (IL)-1β in gingival crevicular fluid (GCF), comparable to IL-1-positive genotype and increased periodontitis severity. Methods: Nineteen non-smoking chronic periodontitis patients using nocturnal occlusal splints and undergoing periodontal maintenance in a private practice were evaluated at five time points: 24 hours after continuous splint use; 1, 2, and 3 days after no occlusal splint use; and 14 days after resumption of customary nighttime splint use. Subjects were evaluated to confirm that the plaque index and gingival index were ≤1.0, and to categorize past periodontitis (moderate or severe) and IL-1 genotype (1A +4845 plus IL-1B +3954). Test sites on two anterior teeth vulnerable to occlusal trauma were sampled for mobility, GCF IL-1β, and IL-1 receptor antagonist (ra). Results: Tooth mobility remained low during the 3-day period when patients were not wearing their occlusal appliance. GCF IL-1β decreased after not wearing the appliances (P = 0.016), especially at 48 hours. At this time, genotype-positive subjects had higher levels of GCF IL-1β/IL-1ra than genotype-negative subjects (P = 0.045), and patients who had experienced severe periodontitis had higher IL-1β levels than moderate periodontitis subjects (P = 0.004). Conclusions: These findings suggest that short-term discontinuation of occlusal splint therapy in non-smoking periodontitis patients undergoing periodontal maintenance does not result in potential signs of early occlusal trauma (increasing mobility or GCF IL-1β). Longer-term studies may be needed to determine appropriate therapy applications for periodontitis-susceptible patients with definable occlusal discrepancies and/or parafunction.

Original languageEnglish (US)
Pages (from-to)1302-1307
Number of pages6
JournalJournal of periodontology
Volume74
Issue number9
DOIs
StatePublished - Sep 1 2003

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Gingival Crevicular Fluid
Periodontitis
Interleukin-1
Occlusal Splints
Genotype
Tooth Mobility
Splints
Interleukins
Maintenance
Bone and Bones
Periodontal Index
Chronic Periodontitis
Interleukin-1 Receptors
Private Practice
Wounds and Injuries
Tooth
Therapeutics
Cytokines

Keywords

  • Gingival crevicular fluid/analysis
  • Interleukin-1
  • Periodontitis/therapy
  • Splints, occlusal
  • Tooth mobility/prevention and control

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Impact of increased occlusal contact, interleukin-1 genotype, and periodontitis severity on gingival crevicular fluid IL-1β levels. / McDevitt, Michael J.; Russell, Carl M.; Schmid, Marian J.; Reinhardt, Richard A.

In: Journal of periodontology, Vol. 74, No. 9, 01.09.2003, p. 1302-1307.

Research output: Contribution to journalArticle

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abstract = "Background: The study of occlusal therapy in humans with periodontitis is problematic due to potential irreversible bone loss in control subjects. The hypothesis of this pilot investigation was that increased interocclusal contact initiated by short-term occlusal splint disuse would increase tooth mobility and the bone-resorptive cytokine interleukin (IL)-1β in gingival crevicular fluid (GCF), comparable to IL-1-positive genotype and increased periodontitis severity. Methods: Nineteen non-smoking chronic periodontitis patients using nocturnal occlusal splints and undergoing periodontal maintenance in a private practice were evaluated at five time points: 24 hours after continuous splint use; 1, 2, and 3 days after no occlusal splint use; and 14 days after resumption of customary nighttime splint use. Subjects were evaluated to confirm that the plaque index and gingival index were ≤1.0, and to categorize past periodontitis (moderate or severe) and IL-1 genotype (1A +4845 plus IL-1B +3954). Test sites on two anterior teeth vulnerable to occlusal trauma were sampled for mobility, GCF IL-1β, and IL-1 receptor antagonist (ra). Results: Tooth mobility remained low during the 3-day period when patients were not wearing their occlusal appliance. GCF IL-1β decreased after not wearing the appliances (P = 0.016), especially at 48 hours. At this time, genotype-positive subjects had higher levels of GCF IL-1β/IL-1ra than genotype-negative subjects (P = 0.045), and patients who had experienced severe periodontitis had higher IL-1β levels than moderate periodontitis subjects (P = 0.004). Conclusions: These findings suggest that short-term discontinuation of occlusal splint therapy in non-smoking periodontitis patients undergoing periodontal maintenance does not result in potential signs of early occlusal trauma (increasing mobility or GCF IL-1β). Longer-term studies may be needed to determine appropriate therapy applications for periodontitis-susceptible patients with definable occlusal discrepancies and/or parafunction.",
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T1 - Impact of increased occlusal contact, interleukin-1 genotype, and periodontitis severity on gingival crevicular fluid IL-1β levels

AU - McDevitt, Michael J.

AU - Russell, Carl M.

AU - Schmid, Marian J.

AU - Reinhardt, Richard A

PY - 2003/9/1

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N2 - Background: The study of occlusal therapy in humans with periodontitis is problematic due to potential irreversible bone loss in control subjects. The hypothesis of this pilot investigation was that increased interocclusal contact initiated by short-term occlusal splint disuse would increase tooth mobility and the bone-resorptive cytokine interleukin (IL)-1β in gingival crevicular fluid (GCF), comparable to IL-1-positive genotype and increased periodontitis severity. Methods: Nineteen non-smoking chronic periodontitis patients using nocturnal occlusal splints and undergoing periodontal maintenance in a private practice were evaluated at five time points: 24 hours after continuous splint use; 1, 2, and 3 days after no occlusal splint use; and 14 days after resumption of customary nighttime splint use. Subjects were evaluated to confirm that the plaque index and gingival index were ≤1.0, and to categorize past periodontitis (moderate or severe) and IL-1 genotype (1A +4845 plus IL-1B +3954). Test sites on two anterior teeth vulnerable to occlusal trauma were sampled for mobility, GCF IL-1β, and IL-1 receptor antagonist (ra). Results: Tooth mobility remained low during the 3-day period when patients were not wearing their occlusal appliance. GCF IL-1β decreased after not wearing the appliances (P = 0.016), especially at 48 hours. At this time, genotype-positive subjects had higher levels of GCF IL-1β/IL-1ra than genotype-negative subjects (P = 0.045), and patients who had experienced severe periodontitis had higher IL-1β levels than moderate periodontitis subjects (P = 0.004). Conclusions: These findings suggest that short-term discontinuation of occlusal splint therapy in non-smoking periodontitis patients undergoing periodontal maintenance does not result in potential signs of early occlusal trauma (increasing mobility or GCF IL-1β). Longer-term studies may be needed to determine appropriate therapy applications for periodontitis-susceptible patients with definable occlusal discrepancies and/or parafunction.

AB - Background: The study of occlusal therapy in humans with periodontitis is problematic due to potential irreversible bone loss in control subjects. The hypothesis of this pilot investigation was that increased interocclusal contact initiated by short-term occlusal splint disuse would increase tooth mobility and the bone-resorptive cytokine interleukin (IL)-1β in gingival crevicular fluid (GCF), comparable to IL-1-positive genotype and increased periodontitis severity. Methods: Nineteen non-smoking chronic periodontitis patients using nocturnal occlusal splints and undergoing periodontal maintenance in a private practice were evaluated at five time points: 24 hours after continuous splint use; 1, 2, and 3 days after no occlusal splint use; and 14 days after resumption of customary nighttime splint use. Subjects were evaluated to confirm that the plaque index and gingival index were ≤1.0, and to categorize past periodontitis (moderate or severe) and IL-1 genotype (1A +4845 plus IL-1B +3954). Test sites on two anterior teeth vulnerable to occlusal trauma were sampled for mobility, GCF IL-1β, and IL-1 receptor antagonist (ra). Results: Tooth mobility remained low during the 3-day period when patients were not wearing their occlusal appliance. GCF IL-1β decreased after not wearing the appliances (P = 0.016), especially at 48 hours. At this time, genotype-positive subjects had higher levels of GCF IL-1β/IL-1ra than genotype-negative subjects (P = 0.045), and patients who had experienced severe periodontitis had higher IL-1β levels than moderate periodontitis subjects (P = 0.004). Conclusions: These findings suggest that short-term discontinuation of occlusal splint therapy in non-smoking periodontitis patients undergoing periodontal maintenance does not result in potential signs of early occlusal trauma (increasing mobility or GCF IL-1β). Longer-term studies may be needed to determine appropriate therapy applications for periodontitis-susceptible patients with definable occlusal discrepancies and/or parafunction.

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KW - Periodontitis/therapy

KW - Splints, occlusal

KW - Tooth mobility/prevention and control

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