Impact of extreme exercise at high altitude on oxidative stress in humans

John Quindry, Charles Dumke, Dustin R Slivka, Brent Ruby

    Research output: Contribution to journalReview article

    21 Citations (Scopus)

    Abstract

    Exercise and oxidative stress research continues to grow as a physiological subdiscipline. The influence of high altitude on exercise and oxidative stress is among the recent topics of intense study in this area. Early findings indicate that exercise at high altitude has an independent influence on free radical generation and the resultant oxidative stress. This review provides a detailed summary of oxidative stress biochemistry as gleaned mainly from studies of humans exercising at high altitude. Understanding of the human response to exercise at altitude is largely derived from field-based research at altitudes above 3000 m in addition to laboratory studies which employ normobaric hypoxia. The implications of oxidative stress incurred during high altitude exercise appear to be a transient increase in oxidative damage followed by redox-sensitive adaptations in multiple tissues. These outcomes are consistent for lowland natives, high altitude acclimated sojourners and highland natives, although the latter group exhibits a more robust adaptive response. To date there is no evidence that altitude-induced oxidative stress is deleterious to normal training or recovery scenarios. Limited evidence suggests that deleterious outcomes related to oxidative stress are limited to instances where individuals are exposed to extreme elevations for extended durations. However, confirmation of this tentative conclusion requires further investigation. More applicably, altitude-induced hypoxia may have an independent influence on redox-sensitive adaptive responses to exercise and exercise recovery. If correct, these findings may hold important implications for athletes, mountaineers, and soldiers working at high altitude. These points are raised within the confines of published research on the topic of oxidative stress during exercise at altitude. (Figure presented.).

    Original languageEnglish (US)
    Pages (from-to)5093-5104
    Number of pages12
    JournalJournal of Physiology
    Volume594
    Issue number18
    DOIs
    StatePublished - Sep 15 2016

    Fingerprint

    Oxidative Stress
    Exercise
    Population Groups
    Oxidation-Reduction
    Research
    Altitude Sickness
    Military Personnel
    Athletes
    Biochemistry
    Free Radicals

    ASJC Scopus subject areas

    • Physiology

    Cite this

    Impact of extreme exercise at high altitude on oxidative stress in humans. / Quindry, John; Dumke, Charles; Slivka, Dustin R; Ruby, Brent.

    In: Journal of Physiology, Vol. 594, No. 18, 15.09.2016, p. 5093-5104.

    Research output: Contribution to journalReview article

    Quindry, John ; Dumke, Charles ; Slivka, Dustin R ; Ruby, Brent. / Impact of extreme exercise at high altitude on oxidative stress in humans. In: Journal of Physiology. 2016 ; Vol. 594, No. 18. pp. 5093-5104.
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