Impact of Altered Methylation in Cytokine Signaling and Proteasome Function in Alcohol and Viral-Mediated Diseases

Kusum Kharbanda, Fawzia Bardag-Gorce, Shirish Barve, Patricia E. Molina, Natalia A Osna

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Data from several laboratories have shown that ethanol (EtOH) feeding impairs many essential methylation reactions that contribute to alcoholic liver disease (ALD). EtOH is also a comorbid factor in the severity of hepatitis C virus-induced liver injury. The presence of viral proteins further exacerbates the methylation defects to disrupt multiple pathways that promote the pathogenesis of liver disease. This review is a compilation of presentations that linked the methylation reaction defects with proteasome inhibition, decreased antigen presentation, and impaired interferon (IFN) signaling in the hepatocytes and dysregulated TNFα expression in macrophages. Two therapeutic modalities, betaine and S-adenosylmethionine, can correct methylation defects to attenuate many EtOH-induced liver changes, as well as improve IFN signaling pathways, thereby overcoming viral treatment resistance.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Methylation
Virus Diseases
Proteasome Endopeptidase Complex
Liver
Alcohols
Cytokines
Defects
Interferons
S-Adenosylmethionine
Betaine
Alcoholic Liver Diseases
Macrophages
Antigen Presentation
Viral Proteins
Viruses
Hepacivirus
Liver Diseases
Hepatocytes
Ethanol
Antigens

Keywords

  • Alcohol
  • Cytokine
  • Methylation
  • Viral

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Impact of Altered Methylation in Cytokine Signaling and Proteasome Function in Alcohol and Viral-Mediated Diseases. / Kharbanda, Kusum; Bardag-Gorce, Fawzia; Barve, Shirish; Molina, Patricia E.; Osna, Natalia A.

In: Alcoholism: Clinical and Experimental Research, Vol. 37, No. 1, 01.01.2013, p. 1-7.

Research output: Contribution to journalReview article

@article{522aea060c9444179c0c9b6a2aad77b2,
title = "Impact of Altered Methylation in Cytokine Signaling and Proteasome Function in Alcohol and Viral-Mediated Diseases",
abstract = "Data from several laboratories have shown that ethanol (EtOH) feeding impairs many essential methylation reactions that contribute to alcoholic liver disease (ALD). EtOH is also a comorbid factor in the severity of hepatitis C virus-induced liver injury. The presence of viral proteins further exacerbates the methylation defects to disrupt multiple pathways that promote the pathogenesis of liver disease. This review is a compilation of presentations that linked the methylation reaction defects with proteasome inhibition, decreased antigen presentation, and impaired interferon (IFN) signaling in the hepatocytes and dysregulated TNFα expression in macrophages. Two therapeutic modalities, betaine and S-adenosylmethionine, can correct methylation defects to attenuate many EtOH-induced liver changes, as well as improve IFN signaling pathways, thereby overcoming viral treatment resistance.",
keywords = "Alcohol, Cytokine, Methylation, Viral",
author = "Kusum Kharbanda and Fawzia Bardag-Gorce and Shirish Barve and Molina, {Patricia E.} and Osna, {Natalia A}",
year = "2013",
month = "1",
day = "1",
doi = "10.1111/j.1530-0277.2012.01840.x",
language = "English (US)",
volume = "37",
pages = "1--7",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Impact of Altered Methylation in Cytokine Signaling and Proteasome Function in Alcohol and Viral-Mediated Diseases

AU - Kharbanda, Kusum

AU - Bardag-Gorce, Fawzia

AU - Barve, Shirish

AU - Molina, Patricia E.

AU - Osna, Natalia A

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Data from several laboratories have shown that ethanol (EtOH) feeding impairs many essential methylation reactions that contribute to alcoholic liver disease (ALD). EtOH is also a comorbid factor in the severity of hepatitis C virus-induced liver injury. The presence of viral proteins further exacerbates the methylation defects to disrupt multiple pathways that promote the pathogenesis of liver disease. This review is a compilation of presentations that linked the methylation reaction defects with proteasome inhibition, decreased antigen presentation, and impaired interferon (IFN) signaling in the hepatocytes and dysregulated TNFα expression in macrophages. Two therapeutic modalities, betaine and S-adenosylmethionine, can correct methylation defects to attenuate many EtOH-induced liver changes, as well as improve IFN signaling pathways, thereby overcoming viral treatment resistance.

AB - Data from several laboratories have shown that ethanol (EtOH) feeding impairs many essential methylation reactions that contribute to alcoholic liver disease (ALD). EtOH is also a comorbid factor in the severity of hepatitis C virus-induced liver injury. The presence of viral proteins further exacerbates the methylation defects to disrupt multiple pathways that promote the pathogenesis of liver disease. This review is a compilation of presentations that linked the methylation reaction defects with proteasome inhibition, decreased antigen presentation, and impaired interferon (IFN) signaling in the hepatocytes and dysregulated TNFα expression in macrophages. Two therapeutic modalities, betaine and S-adenosylmethionine, can correct methylation defects to attenuate many EtOH-induced liver changes, as well as improve IFN signaling pathways, thereby overcoming viral treatment resistance.

KW - Alcohol

KW - Cytokine

KW - Methylation

KW - Viral

UR - http://www.scopus.com/inward/record.url?scp=84871964152&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871964152&partnerID=8YFLogxK

U2 - 10.1111/j.1530-0277.2012.01840.x

DO - 10.1111/j.1530-0277.2012.01840.x

M3 - Review article

VL - 37

SP - 1

EP - 7

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 1

ER -