Immunotherapeutic Potential in Murine Tumor Models of Polyinosinic-Polycytidylic Acid and Poly-L-lysine Solubilized by Carboxymethylcellulose

James E. Talmadge, Joanne Adams, Hamblin Phillips, Margaret Collins, Barbara Lenz, Mark Schneider, Michael Chirigos, James E. Talmadge

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Abstract

The systemic administration of multiple, nontoxic doses of polyinosinic-polycytidylic acid and poly-L-lysine solubilized by carboxymethylcellulose [poly(l,C)-LC] eradicated established experimental and spontaneous pulmonary metastases. Optimal immunotherapy was schedule dependent, requiring three to five injections of poly(l,C)-LC per week for a minimum of 4 weeks; in addition, therapeutic efficiency was partially dosage independent. Immunotherapy by poly(l,C)-LC was found to be limited by tumor burden, although when combined with chemotherapy as a de-bulking regimen it resulted in increased survival with protocols in which poly(l,C)-LC alone was insufficient. These data suggest that the systemic administration of Poly(l,C)-LC may provide a successful adjuvant therapeutic modality against cancer metastasis.

Original languageEnglish (US)
Pages (from-to)1066-1072
Number of pages7
JournalCancer Research
Volume45
Issue number3
Publication statusPublished - Mar 1 1985

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Talmadge, J. E., Adams, J., Phillips, H., Collins, M., Lenz, B., Schneider, M., ... Talmadge, J. E. (1985). Immunotherapeutic Potential in Murine Tumor Models of Polyinosinic-Polycytidylic Acid and Poly-L-lysine Solubilized by Carboxymethylcellulose. Cancer Research, 45(3), 1066-1072.