The systemic administration of multiple, nontoxic doses of polyinosinic-polycytidylic acid and poly-L-lysine solubilized by carboxymethylcellulose [poly(l,C)-LC] eradicated established experimental and spontaneous pulmonary metastases. Optimal immunotherapy was schedule dependent, requiring three to five injections of poly(l,C)-LC per week for a minimum of 4 weeks; in addition, therapeutic efficiency was partially dosage independent. Immunotherapy by poly(l,C)-LC was found to be limited by tumor burden, although when combined with chemotherapy as a de-bulking regimen it resulted in increased survival with protocols in which poly(l,C)-LC alone was insufficient. These data suggest that the systemic administration of Poly(l,C)-LC may provide a successful adjuvant therapeutic modality against cancer metastasis.
|Original language||English (US)|
|Number of pages||7|
|Publication status||Published - Mar 1 1985|
ASJC Scopus subject areas
- Cancer Research