Immunosuppressive effects of ganciclovir on in vitro lymphocyte responses

Raleigh A. Bowden, Jon Digel, Elizabeth C. Reed, Joel D. Meyers

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

We evaluated the effect of ganciclovir on in vitro immune responses by lymphocytes from healthy individuals. At clinically relevant concentrations, ganciclovir inhibited proliferation responses to cytomegalovirus antigen and to phytohemagglutinin by b50% but had no effect on production of interleukin-2 or γ interferon to these stimuli or on cytotoxicity against cytomegalovirus-infected, HLA-mismatched target cells. These results showed that ganciclovir inhibits lymphocyte functions for which lymphocyte proliferation is required but does not affect lymphocyte responses that do not require DNA synthesis. Studies of the effect on the immune responses in patients receiving ganciclovir will be needed to determine in vivo correlates of these findings.

Original languageEnglish (US)
Pages (from-to)899-903
Number of pages5
JournalJournal of Infectious Diseases
Volume156
Issue number6
DOIs
Publication statusPublished - Dec 1987

    Fingerprint

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this