Immunosuppressive effects of ganciclovir on in vitro lymphocyte responses

Raleigh A. Bowden, Jon Digel, Elizabeth C. Reed, Joel D. Meyers

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

We evaluated the effect of ganciclovir on in vitro immune responses by lymphocytes from healthy individuals. At clinically relevant concentrations, ganciclovir inhibited proliferation responses to cytomegalovirus antigen and to phytohemagglutinin by b50% but had no effect on production of interleukin-2 or γ interferon to these stimuli or on cytotoxicity against cytomegalovirus-infected, HLA-mismatched target cells. These results showed that ganciclovir inhibits lymphocyte functions for which lymphocyte proliferation is required but does not affect lymphocyte responses that do not require DNA synthesis. Studies of the effect on the immune responses in patients receiving ganciclovir will be needed to determine in vivo correlates of these findings.

Original languageEnglish (US)
Pages (from-to)899-903
Number of pages5
JournalJournal of Infectious Diseases
Volume156
Issue number6
DOIs
StatePublished - Dec 1987

Fingerprint

Ganciclovir
Immunosuppressive Agents
Lymphocytes
Cytomegalovirus
Phytohemagglutinins
Interferons
Interleukin-2
Antigens
In Vitro Techniques
DNA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Immunosuppressive effects of ganciclovir on in vitro lymphocyte responses. / Bowden, Raleigh A.; Digel, Jon; Reed, Elizabeth C.; Meyers, Joel D.

In: Journal of Infectious Diseases, Vol. 156, No. 6, 12.1987, p. 899-903.

Research output: Contribution to journalArticle

Bowden, Raleigh A. ; Digel, Jon ; Reed, Elizabeth C. ; Meyers, Joel D. / Immunosuppressive effects of ganciclovir on in vitro lymphocyte responses. In: Journal of Infectious Diseases. 1987 ; Vol. 156, No. 6. pp. 899-903.
@article{d45e0b37bebb465c8ae37afe7536eaaf,
title = "Immunosuppressive effects of ganciclovir on in vitro lymphocyte responses",
abstract = "We evaluated the effect of ganciclovir on in vitro immune responses by lymphocytes from healthy individuals. At clinically relevant concentrations, ganciclovir inhibited proliferation responses to cytomegalovirus antigen and to phytohemagglutinin by b50{\%} but had no effect on production of interleukin-2 or γ interferon to these stimuli or on cytotoxicity against cytomegalovirus-infected, HLA-mismatched target cells. These results showed that ganciclovir inhibits lymphocyte functions for which lymphocyte proliferation is required but does not affect lymphocyte responses that do not require DNA synthesis. Studies of the effect on the immune responses in patients receiving ganciclovir will be needed to determine in vivo correlates of these findings.",
author = "Bowden, {Raleigh A.} and Jon Digel and Reed, {Elizabeth C.} and Meyers, {Joel D.}",
year = "1987",
month = "12",
doi = "10.1093/infdis/156.6.899",
language = "English (US)",
volume = "156",
pages = "899--903",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Immunosuppressive effects of ganciclovir on in vitro lymphocyte responses

AU - Bowden, Raleigh A.

AU - Digel, Jon

AU - Reed, Elizabeth C.

AU - Meyers, Joel D.

PY - 1987/12

Y1 - 1987/12

N2 - We evaluated the effect of ganciclovir on in vitro immune responses by lymphocytes from healthy individuals. At clinically relevant concentrations, ganciclovir inhibited proliferation responses to cytomegalovirus antigen and to phytohemagglutinin by b50% but had no effect on production of interleukin-2 or γ interferon to these stimuli or on cytotoxicity against cytomegalovirus-infected, HLA-mismatched target cells. These results showed that ganciclovir inhibits lymphocyte functions for which lymphocyte proliferation is required but does not affect lymphocyte responses that do not require DNA synthesis. Studies of the effect on the immune responses in patients receiving ganciclovir will be needed to determine in vivo correlates of these findings.

AB - We evaluated the effect of ganciclovir on in vitro immune responses by lymphocytes from healthy individuals. At clinically relevant concentrations, ganciclovir inhibited proliferation responses to cytomegalovirus antigen and to phytohemagglutinin by b50% but had no effect on production of interleukin-2 or γ interferon to these stimuli or on cytotoxicity against cytomegalovirus-infected, HLA-mismatched target cells. These results showed that ganciclovir inhibits lymphocyte functions for which lymphocyte proliferation is required but does not affect lymphocyte responses that do not require DNA synthesis. Studies of the effect on the immune responses in patients receiving ganciclovir will be needed to determine in vivo correlates of these findings.

UR - http://www.scopus.com/inward/record.url?scp=0023555690&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023555690&partnerID=8YFLogxK

U2 - 10.1093/infdis/156.6.899

DO - 10.1093/infdis/156.6.899

M3 - Article

C2 - 2824624

AN - SCOPUS:0023555690

VL - 156

SP - 899

EP - 903

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 6

ER -