Immunostimulating properties of the complexes of inosine derivatives

Larisa Poluektova, Yuris Maurinsh, Margeris Lidaks, Nadja Gromova

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Abstract

The effects of the complexes of inosine (Ino) analogues of isoprinosine on the immune response to sheep red blood cells (SRBC), in plaque-forming cells assay (PFC), in mice spleen, and on the Fc-dependent SRBC phagocytosis in mice peritoneal macrophages were investigated. Molar ratios of 1:3 of the complexes of inosine with N,N-dimethylaminopropanol-2-p-acetaminobenzoate (isoprinosine), and 8-thioinosine with N,N-dimethylaminopropanol-2-p-acetaminobenzoate (OSI-177), inosine with l-arginine butyrate (OSI-2655), and 8-thioinosine with l-arginine butyrate (OSI-3648) were administered. The administered doses were 0.5, 5 and 50 mg/kg body weight. The compound OSI-2655 exceeded isoprinosine in PFC stimulation and phagocytosis activation. The compound OSI-3648 exceeded isoprinosine only in PFC stimulation in the case of immunization with a suboptimal SRBC dose. OSI-3648 stimulated the immune response in PFC better than isoprinosine, OSI177, or OSI-2655, and maintained the ability to stimulate capture, but lost the ability to stimulate destruction processes of captured SRBC. l-Arginine butyrate in the doses equivalent to its content in the complexes did not affect the number of PFC. l-Arginine butyrate was able to stimulate the processes of destruction but its stimulation degree was inferior to the compound OSI-2655.

Original languageEnglish (US)
Pages (from-to)941-947
Number of pages7
JournalInternational Journal of Immunopharmacology
Volume17
Issue number11
DOIs
StatePublished - Nov 1995

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Keywords

  • immunostimulation
  • inosine
  • isoprinosine

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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