Immunophenotypic and genotypic characterization of lymphomatoid papulosis

Jeff D. Parks, Mark S. Synovec, Aneal S. Masih, Suzanne W. Braddock, Hirokazu Nakamine, Warren G. Sanger, Douglas S. Harrington, Dennis D. Weisenburger

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Lymphomatoid papulosis (LyP) is a chronic dermatosis that histologically resembles malignant lymphoma. Thus far, only a few cases of LyP have been characterized in detail with regard to immunophenotype, genotype, and karyotype. Objective: Our purpose was to study seven patients with LyP and compare the results to those reported in the literature. Methods: Skin biopsy specimens were analyzed by frozen section immunohistochemical and molecular biologic techniques. Cytogenetic analysis was also performed in three cases. Results: The atypical lymphoid cells consisted of activated helper T cells; four of the seven patients had lesions with a detectable clonal T-cell population. A peripheral T-cell lymphoma developed in one patient before the emergence of a genotypically different LyP T-cell clone. Cytogenetic studies were abnormal in one case of LyP and normal in another, whereas the karyotype of the lymphoma was abnormal. Conclusion: LyP is a preneoplastic proliferation of activated helper T cells, which is often clonal and may regress and expand with the development of new LyP clones or lymphoma.

Original languageEnglish (US)
Pages (from-to)968-975
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume26
Issue number6
DOIs
StatePublished - Jan 1 1992

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Lymphomatoid Papulosis
Lymphoma
Helper-Inducer T-Lymphocytes
Karyotype
Clone Cells
Peripheral T-Cell Lymphoma
T-Lymphocytes
Cytogenetic Analysis
Frozen Sections
Skin Diseases
Cytogenetics
Genotype
Lymphocytes
Biopsy
Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

Parks, J. D., Synovec, M. S., Masih, A. S., Braddock, S. W., Nakamine, H., Sanger, W. G., ... Weisenburger, D. D. (1992). Immunophenotypic and genotypic characterization of lymphomatoid papulosis. Journal of the American Academy of Dermatology, 26(6), 968-975. https://doi.org/10.1016/0190-9622(92)70143-4

Immunophenotypic and genotypic characterization of lymphomatoid papulosis. / Parks, Jeff D.; Synovec, Mark S.; Masih, Aneal S.; Braddock, Suzanne W.; Nakamine, Hirokazu; Sanger, Warren G.; Harrington, Douglas S.; Weisenburger, Dennis D.

In: Journal of the American Academy of Dermatology, Vol. 26, No. 6, 01.01.1992, p. 968-975.

Research output: Contribution to journalArticle

Parks, JD, Synovec, MS, Masih, AS, Braddock, SW, Nakamine, H, Sanger, WG, Harrington, DS & Weisenburger, DD 1992, 'Immunophenotypic and genotypic characterization of lymphomatoid papulosis', Journal of the American Academy of Dermatology, vol. 26, no. 6, pp. 968-975. https://doi.org/10.1016/0190-9622(92)70143-4
Parks, Jeff D. ; Synovec, Mark S. ; Masih, Aneal S. ; Braddock, Suzanne W. ; Nakamine, Hirokazu ; Sanger, Warren G. ; Harrington, Douglas S. ; Weisenburger, Dennis D. / Immunophenotypic and genotypic characterization of lymphomatoid papulosis. In: Journal of the American Academy of Dermatology. 1992 ; Vol. 26, No. 6. pp. 968-975.
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