Abstract

PURPOSE OF REVIEW: Agriculture represents a major industry worldwide, and despite protection against the development of IgE-mediated diseases, chronic exposure to agriculture-related organic dusts is associated with an increased risk of developing respiratory disease. This article will review the literature regarding new knowledge of important etiologic agents in the dusts and focus on the immunologic responses following acute and repetitive organic dust exposures. RECENT FINDINGS: Although endotoxin remains important, there is an emerging role of nonendotoxin components such as peptidoglycans from Gram-positive bacteria. Pattern recognition receptors including Toll-like receptor 4 (TLR4), TLR2 and intracellular nucleotide oligomerization domain-like receptors are partially responsible for mediating the inflammatory consequences. Repeated organic dust exposures modulate innate and adaptive immune function with a resultant adaptation-like response. However, repetitive exposures cause lung parenchymal inflammation, chronic disease, and lung function decline over time. SUMMARY: The immunological consequences of organic dust exposure in the farming industry are likely explained by the diversity of microbial motifs in dust that can elicit differing innate immune receptor signaling pathways. Whereas initial activation results in a robust inflammatory response, repetitive dust exposures modulate immunity. This can result in low-grade, chronic inflammation, and/or protection against allergic disease.

Original languageEnglish (US)
Pages (from-to)126-132
Number of pages7
JournalCurrent opinion in allergy and clinical immunology
Volume12
Issue number2
DOIs
StatePublished - Apr 1 2012

Fingerprint

Agriculture
Dust
Industry
Chronic Disease
Organic Agriculture
Pattern Recognition Receptors
Toll-Like Receptor 4
Peptidoglycan
Gram-Positive Bacteria
Endotoxins
Immunoglobulin E
Immunity
Pneumonia
Nucleotides
Inflammation
Lung

Keywords

  • adaptation
  • endotoxin
  • farm
  • innate immunity
  • pattern recognition receptors
  • peptidoglycan
  • respiratory disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Immunological and inflammatory responses to organic dust in agriculture. / Poole, Jill A; Romberger, Debra.

In: Current opinion in allergy and clinical immunology, Vol. 12, No. 2, 01.04.2012, p. 126-132.

Research output: Contribution to journalReview article

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