Immunologic memory 5 years after meningococcal A/C conjugate vaccination in infancy

Jenny M. MacLennan, Stephen K Obaro, Jonathan Deeks, Derrick Lake, Cheryl Elie, George Carlone, E. Richard Moxon, Brian Greenwood

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Abstract

Infant vaccination with meningococcal conjugates may provide long-term protection against disease. Antibody levels and immunologic memory were assessed in 5-year-old Gambian children who received meningococcal A/C conjugate vaccination (MenA/C) in infancy. At 2 years, they were randomized to receive a booster of MenA/C (conjugate group), meningococcal A/C polysaccharide (MPS group), or inactivated polio vaccine (PV group). All groups were revaccinated with 10 μg MPS at 5 years of age, as were 39 previously unvaccinated age-matched control subjects. Before revaccination, titers were higher in the conjugate and MPS groups than in control subjects (P<.001); titers for the IPV group were similar to those for control subjects. Ten days after revaccination, the conjugate and IPV groups had similar serogroup C serum bactericidal antibody titers (3421 vs. 2790, respectively). These levels were significantly higher than those in the MPS (426) and control (485) groups (P< .001). Thus, immunologic memory was sustained for ≥5 years; however, MPS challenge at 2 years interfered with a subsequent memory response.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalJournal of Infectious Diseases
Volume183
Issue number1
DOIs
StatePublished - Jan 1 2001

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Immunologic Memory
Secondary Immunization
Vaccination
Control Groups
Inactivated Vaccines
Antibodies
Poliomyelitis
Serum

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

MacLennan, J. M., Obaro, S. K., Deeks, J., Lake, D., Elie, C., Carlone, G., ... Greenwood, B. (2001). Immunologic memory 5 years after meningococcal A/C conjugate vaccination in infancy. Journal of Infectious Diseases, 183(1), 97-104. https://doi.org/10.1086/317667

Immunologic memory 5 years after meningococcal A/C conjugate vaccination in infancy. / MacLennan, Jenny M.; Obaro, Stephen K; Deeks, Jonathan; Lake, Derrick; Elie, Cheryl; Carlone, George; Moxon, E. Richard; Greenwood, Brian.

In: Journal of Infectious Diseases, Vol. 183, No. 1, 01.01.2001, p. 97-104.

Research output: Contribution to journalArticle

MacLennan, JM, Obaro, SK, Deeks, J, Lake, D, Elie, C, Carlone, G, Moxon, ER & Greenwood, B 2001, 'Immunologic memory 5 years after meningococcal A/C conjugate vaccination in infancy', Journal of Infectious Diseases, vol. 183, no. 1, pp. 97-104. https://doi.org/10.1086/317667
MacLennan, Jenny M. ; Obaro, Stephen K ; Deeks, Jonathan ; Lake, Derrick ; Elie, Cheryl ; Carlone, George ; Moxon, E. Richard ; Greenwood, Brian. / Immunologic memory 5 years after meningococcal A/C conjugate vaccination in infancy. In: Journal of Infectious Diseases. 2001 ; Vol. 183, No. 1. pp. 97-104.
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