Immunologic and histologic evaluation of the urinary bladder wall after group A streptococcal infection

Stanton D Harn, H. J. Keutel, R. G. Weaver

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A progressive chronic inflammation characterized by acute intermittent exacerbations was produced by injection of small numbers of Group A, type 12, S. pyogenes into the bladder wall of rabbits. A quantitative cell count on serially sacrificed rabbits was made. The cellular response was found to be greatly altered and dependent upon the tissue layer of the bladder wall injected. With chronicity of the lesions, tissue injury and alterations were prominent. Concomitantly, tissue DNA fluorescence using acridine orange was found to be reduced. Tissue DNA antibodies were demonstrated in all rabbits injected with streptococci. These antibodies were also demonstrated in a human patient with the clinical diagnosis of interstitial cystititis. Streptococcal antigens were found to be present in the bladder tissue long after viability had ceased using immunofluorescence. A relation between cystitis, interstitial cystitis, and streptococcal and poststreptococcal inflammation is suggested.

Original languageEnglish (US)
Pages (from-to)55-64
Number of pages10
JournalInvestigative Urology
Volume11
Issue number1
StatePublished - Dec 1 1973

Fingerprint

Streptococcal Infections
Urinary Bladder
Rabbits
Inflammation
Interstitial Cystitis
Acridine Orange
Cystitis
Antibodies
DNA
Streptococcus
Fluorescent Antibody Technique
Cell Count
Fluorescence
Antigens
Injections
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Immunologic and histologic evaluation of the urinary bladder wall after group A streptococcal infection. / Harn, Stanton D; Keutel, H. J.; Weaver, R. G.

In: Investigative Urology, Vol. 11, No. 1, 01.12.1973, p. 55-64.

Research output: Contribution to journalArticle

Harn, Stanton D ; Keutel, H. J. ; Weaver, R. G. / Immunologic and histologic evaluation of the urinary bladder wall after group A streptococcal infection. In: Investigative Urology. 1973 ; Vol. 11, No. 1. pp. 55-64.
@article{6868d0437aff48a980d1576968ca4b4d,
title = "Immunologic and histologic evaluation of the urinary bladder wall after group A streptococcal infection",
abstract = "A progressive chronic inflammation characterized by acute intermittent exacerbations was produced by injection of small numbers of Group A, type 12, S. pyogenes into the bladder wall of rabbits. A quantitative cell count on serially sacrificed rabbits was made. The cellular response was found to be greatly altered and dependent upon the tissue layer of the bladder wall injected. With chronicity of the lesions, tissue injury and alterations were prominent. Concomitantly, tissue DNA fluorescence using acridine orange was found to be reduced. Tissue DNA antibodies were demonstrated in all rabbits injected with streptococci. These antibodies were also demonstrated in a human patient with the clinical diagnosis of interstitial cystititis. Streptococcal antigens were found to be present in the bladder tissue long after viability had ceased using immunofluorescence. A relation between cystitis, interstitial cystitis, and streptococcal and poststreptococcal inflammation is suggested.",
author = "Harn, {Stanton D} and Keutel, {H. J.} and Weaver, {R. G.}",
year = "1973",
month = "12",
day = "1",
language = "English (US)",
volume = "11",
pages = "55--64",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Immunologic and histologic evaluation of the urinary bladder wall after group A streptococcal infection

AU - Harn, Stanton D

AU - Keutel, H. J.

AU - Weaver, R. G.

PY - 1973/12/1

Y1 - 1973/12/1

N2 - A progressive chronic inflammation characterized by acute intermittent exacerbations was produced by injection of small numbers of Group A, type 12, S. pyogenes into the bladder wall of rabbits. A quantitative cell count on serially sacrificed rabbits was made. The cellular response was found to be greatly altered and dependent upon the tissue layer of the bladder wall injected. With chronicity of the lesions, tissue injury and alterations were prominent. Concomitantly, tissue DNA fluorescence using acridine orange was found to be reduced. Tissue DNA antibodies were demonstrated in all rabbits injected with streptococci. These antibodies were also demonstrated in a human patient with the clinical diagnosis of interstitial cystititis. Streptococcal antigens were found to be present in the bladder tissue long after viability had ceased using immunofluorescence. A relation between cystitis, interstitial cystitis, and streptococcal and poststreptococcal inflammation is suggested.

AB - A progressive chronic inflammation characterized by acute intermittent exacerbations was produced by injection of small numbers of Group A, type 12, S. pyogenes into the bladder wall of rabbits. A quantitative cell count on serially sacrificed rabbits was made. The cellular response was found to be greatly altered and dependent upon the tissue layer of the bladder wall injected. With chronicity of the lesions, tissue injury and alterations were prominent. Concomitantly, tissue DNA fluorescence using acridine orange was found to be reduced. Tissue DNA antibodies were demonstrated in all rabbits injected with streptococci. These antibodies were also demonstrated in a human patient with the clinical diagnosis of interstitial cystititis. Streptococcal antigens were found to be present in the bladder tissue long after viability had ceased using immunofluorescence. A relation between cystitis, interstitial cystitis, and streptococcal and poststreptococcal inflammation is suggested.

UR - http://www.scopus.com/inward/record.url?scp=0015793707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015793707&partnerID=8YFLogxK

M3 - Article

VL - 11

SP - 55

EP - 64

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 1

ER -