Immunohistochemical staining of CD10 in atypical fibroxanthomas

Tricia L. Hultgren, Dominick J DiMaio

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Background: The histologic diagnosis of atypical fibroxanthoma (AFX) may be difficult at times with a differential diagnosis including spindle cell/desmoplastic melanoma and a poorly differentiated squamous cell carcinoma (SCC). While there are immunohistochemical stains that may be used to support a diagnosis of either melanoma or carcinoma, the diagnosis of AFX tends to be one of exclusion. Methods: A total of 35 cases including 16 AFXs, 10 poorly differentiated SCCs and nine spindle cell/desmoplastic melanomas were stained with the antibody against CD10. Results: There was strong (3+) diffuse expression of CD10 in 15/16 (94%) AFXs, weak (1+) to moderate (2+) patchy expression of CD10 in 5/10 (50%) SCCs and weak (1+) expression of CD10 in 3/9 (33%) spindle cell/desmoplastic melanomas. Conclusion: CD10 expression is helpful in distinguishing between AFXs, carcinomas and melanomas and will be useful in a panel of antibodies when distinguishing between these entities.

Original languageEnglish (US)
Pages (from-to)415-419
Number of pages5
JournalJournal of Cutaneous Pathology
Volume34
Issue number5
DOIs
StatePublished - May 1 2007

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Melanoma
Staining and Labeling
Carcinoma
Antibodies
Squamous Cell Carcinoma
Differential Diagnosis
Coloring Agents

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Cite this

Immunohistochemical staining of CD10 in atypical fibroxanthomas. / Hultgren, Tricia L.; DiMaio, Dominick J.

In: Journal of Cutaneous Pathology, Vol. 34, No. 5, 01.05.2007, p. 415-419.

Research output: Contribution to journalArticle

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abstract = "Background: The histologic diagnosis of atypical fibroxanthoma (AFX) may be difficult at times with a differential diagnosis including spindle cell/desmoplastic melanoma and a poorly differentiated squamous cell carcinoma (SCC). While there are immunohistochemical stains that may be used to support a diagnosis of either melanoma or carcinoma, the diagnosis of AFX tends to be one of exclusion. Methods: A total of 35 cases including 16 AFXs, 10 poorly differentiated SCCs and nine spindle cell/desmoplastic melanomas were stained with the antibody against CD10. Results: There was strong (3+) diffuse expression of CD10 in 15/16 (94{\%}) AFXs, weak (1+) to moderate (2+) patchy expression of CD10 in 5/10 (50{\%}) SCCs and weak (1+) expression of CD10 in 3/9 (33{\%}) spindle cell/desmoplastic melanomas. Conclusion: CD10 expression is helpful in distinguishing between AFXs, carcinomas and melanomas and will be useful in a panel of antibodies when distinguishing between these entities.",
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AB - Background: The histologic diagnosis of atypical fibroxanthoma (AFX) may be difficult at times with a differential diagnosis including spindle cell/desmoplastic melanoma and a poorly differentiated squamous cell carcinoma (SCC). While there are immunohistochemical stains that may be used to support a diagnosis of either melanoma or carcinoma, the diagnosis of AFX tends to be one of exclusion. Methods: A total of 35 cases including 16 AFXs, 10 poorly differentiated SCCs and nine spindle cell/desmoplastic melanomas were stained with the antibody against CD10. Results: There was strong (3+) diffuse expression of CD10 in 15/16 (94%) AFXs, weak (1+) to moderate (2+) patchy expression of CD10 in 5/10 (50%) SCCs and weak (1+) expression of CD10 in 3/9 (33%) spindle cell/desmoplastic melanomas. Conclusion: CD10 expression is helpful in distinguishing between AFXs, carcinomas and melanomas and will be useful in a panel of antibodies when distinguishing between these entities.

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