Immunodeficiency-associated lymphomas

Huy Tran, Jamie Nourse, Sara Hall, Michael R Green, Lyn Griffiths, Maher K. Gandhi

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

This article covers lymphoproliferative disorders in patients with primary or acquired immunodeficiencies. Primary immunodeficiences include Ataxia Telangiectasia and X-linked disorders such as Wiskott-Aldrich syndrome. Acquired immunodeficiencies predominantly occur in the setting of infection with the Human Immunodeficiency Virus or arise following immunosuppressive therapy administered after organ transplantation. The rising incidence of HIV throughout the world and the dramatic increase in transplant surgery since the 1990's suggest that these lymphomas will remain an important health problem. Evidence for lymphoma developing as a result of treatment with methotrexate or Tumour Necrosis Factor Antagonists for autoimmune entities will also be reviewed. The lymphoproliferations that occur with immunodeficiency are extremely heterogenous. In part this reflects the diversity of the causal immune defect. The most striking clinical characteristic is the high frequency of extranodal disease. Frequently, these lymphomas are driven by viruses such as Epstein-Barr virus (EBV), although the lack of EBV in a proportion indicates that alternate pathways must also be involved in the pathogenesis. Lastly, discussion will centre on mechanisms utilized by lymphomas in the immunodeficient as these may have applications to lymphomas in the "immunocompetent", by serving as a paradigm for the altered immunoregulatory environment present in many lymphoma sub-types.

Original languageEnglish (US)
Pages (from-to)261-281
Number of pages21
JournalBlood Reviews
Volume22
Issue number5
DOIs
StatePublished - Sep 1 2008

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Lymphoma
Human Herpesvirus 4
HIV
Wiskott-Aldrich Syndrome
Ataxia Telangiectasia
Lymphoproliferative Disorders
Organ Transplantation
Immunosuppressive Agents
Methotrexate
Tumor Necrosis Factor-alpha
Viruses
Transplants
Incidence
Health
Therapeutics
Infection

Keywords

  • Ataxia Telangiectasia
  • Combined variable immunodeficiency disorder
  • Diffuse large B cell lymphoma
  • Epstein-barr virus
  • Hodgkin's lymphoma
  • Human herpes virus 8
  • Human immunodeficiency virus
  • Immunodeficiency
  • Infliximab
  • Lymphoma
  • Methotrexate
  • Post-transplantation lymphoproliferative disorder
  • Primary central nervous system lymphoma
  • Primary effusion lymphoma
  • Rituximab

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Tran, H., Nourse, J., Hall, S., Green, M. R., Griffiths, L., & Gandhi, M. K. (2008). Immunodeficiency-associated lymphomas. Blood Reviews, 22(5), 261-281. https://doi.org/10.1016/j.blre.2008.03.009

Immunodeficiency-associated lymphomas. / Tran, Huy; Nourse, Jamie; Hall, Sara; Green, Michael R; Griffiths, Lyn; Gandhi, Maher K.

In: Blood Reviews, Vol. 22, No. 5, 01.09.2008, p. 261-281.

Research output: Contribution to journalArticle

Tran, H, Nourse, J, Hall, S, Green, MR, Griffiths, L & Gandhi, MK 2008, 'Immunodeficiency-associated lymphomas', Blood Reviews, vol. 22, no. 5, pp. 261-281. https://doi.org/10.1016/j.blre.2008.03.009
Tran H, Nourse J, Hall S, Green MR, Griffiths L, Gandhi MK. Immunodeficiency-associated lymphomas. Blood Reviews. 2008 Sep 1;22(5):261-281. https://doi.org/10.1016/j.blre.2008.03.009
Tran, Huy ; Nourse, Jamie ; Hall, Sara ; Green, Michael R ; Griffiths, Lyn ; Gandhi, Maher K. / Immunodeficiency-associated lymphomas. In: Blood Reviews. 2008 ; Vol. 22, No. 5. pp. 261-281.
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