Immunocompromise in gnotobiotic pigs induced by verotoxin-producing Escherichia coli (O111:NM)

J. Christopher-Hennings, J. A. Willgohs, D. H. Francis, U. A.K. Raman, R. A. Moxley, D. J. Hurley

Research output: Contribution to journalArticle

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Abstract

A verotoxin-producing Escherichia coli serotype O111:NM strain (strain 10049; verotoxin 1 positive) persistently infected experimentally inoculated gnotobiotic pigs, causing attaching-effacing intestinal lesions and chronic diarrhea. Experiments were performed to determine whether persistent infection might be associated with immunocompromise of the host by this organism. Pigs inoculated with this strain had a significant reduction in peripheral blood lymphocytes and lower antibody titers to sheep erythrocytes compared with control pigs. Compared with pigs given a verotoxin-negative pathogenic strain of the same serotype (O111:NM, strain 2430), pigs inoculated with the verotoxin-positive strain had lower peripheral lymphocyte counts and proliferative responses to concanavalin A, phytohemagglutinin, and pokeweed mitogens. The results of this study suggest that strain 10049 has an immunocompromising effect on gnotobiotic pigs.

Original languageEnglish (US)
Pages (from-to)2304-2308
Number of pages5
JournalInfection and immunity
Volume61
Issue number6
StatePublished - Jan 1 1993

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Germ-Free Life
Shiga-Toxigenic Escherichia coli
Swine
Shiga Toxins
Pokeweed Mitogens
Lymphocyte Count
Phytohemagglutinins
Concanavalin A
Diarrhea
Sheep
Erythrocytes
Lymphocytes
Antibodies
Infection

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Christopher-Hennings, J., Willgohs, J. A., Francis, D. H., Raman, U. A. K., Moxley, R. A., & Hurley, D. J. (1993). Immunocompromise in gnotobiotic pigs induced by verotoxin-producing Escherichia coli (O111:NM). Infection and immunity, 61(6), 2304-2308.

Immunocompromise in gnotobiotic pigs induced by verotoxin-producing Escherichia coli (O111:NM). / Christopher-Hennings, J.; Willgohs, J. A.; Francis, D. H.; Raman, U. A.K.; Moxley, R. A.; Hurley, D. J.

In: Infection and immunity, Vol. 61, No. 6, 01.01.1993, p. 2304-2308.

Research output: Contribution to journalArticle

Christopher-Hennings, J, Willgohs, JA, Francis, DH, Raman, UAK, Moxley, RA & Hurley, DJ 1993, 'Immunocompromise in gnotobiotic pigs induced by verotoxin-producing Escherichia coli (O111:NM)', Infection and immunity, vol. 61, no. 6, pp. 2304-2308.
Christopher-Hennings J, Willgohs JA, Francis DH, Raman UAK, Moxley RA, Hurley DJ. Immunocompromise in gnotobiotic pigs induced by verotoxin-producing Escherichia coli (O111:NM). Infection and immunity. 1993 Jan 1;61(6):2304-2308.
Christopher-Hennings, J. ; Willgohs, J. A. ; Francis, D. H. ; Raman, U. A.K. ; Moxley, R. A. ; Hurley, D. J. / Immunocompromise in gnotobiotic pigs induced by verotoxin-producing Escherichia coli (O111:NM). In: Infection and immunity. 1993 ; Vol. 61, No. 6. pp. 2304-2308.
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