Immunoblastic lymphoma with abundant clear cytoplasm

A comparative study of B- and T-cell types

H. Nakamine, A. S. Masih, R. S. Strobach, M. J. Duggan, M. A. Bast, James Olen Armitage, D. D. Weisenburger

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The morphologic, phenotypic, molecular genetic, and clinical features of 34 cases of clear-cell immunoblastic lymphoma (IBLC) are described. Sixteen cases were of B-cell type (IBLC-B) and 18 cases were of T-cell type (IBLC-T). There were no significant differences in the morphologic characteristics of the neoplastic cells in the two types, although IBLC-B was less likely to be polymorphic than IBLC-T. Interfollicular proliferation, a higher mitotic rate, infiltration by eosinophils, and an increase in capillary-sized blood vessels were also features of IBLC-T, whereas necrosis and fibrosis were more extensive in IBLC-B. Patients with IBLC-B were predominantly female, whereas those with IBLC-T were predominantly male. The mean age was 62 years for those with IBLC-B and 46 years for those with IBLC-T. Patients with IBLC-B usually had lower-stage disease, but there was no significant difference in survival rate between those with IBLC-B and those with IBLC-T. Although most cases of IBLC have been considered to be of peripheral T-cell origin, the authors conclude that IBLC-B is more common than previously considered and that clear-cell morphologic characteristics are not a reliable indicator of T-cell type.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalAmerican journal of clinical pathology
Volume96
Issue number2
DOIs
StatePublished - Jan 1 1991

Fingerprint

Lymphoma
Cytoplasm
T-Lymphocytes
T-Cell Lymphoma
B-Cell Lymphoma
Eosinophils
Blood Vessels
Molecular Biology
Fibrosis
Necrosis
Survival Rate

Keywords

  • B-cell lymphoma
  • Clear cell
  • Immunoblastic lymphoma
  • Non-Hodgkin's lymphoma
  • Peripheral T-cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Immunoblastic lymphoma with abundant clear cytoplasm : A comparative study of B- and T-cell types. / Nakamine, H.; Masih, A. S.; Strobach, R. S.; Duggan, M. J.; Bast, M. A.; Armitage, James Olen; Weisenburger, D. D.

In: American journal of clinical pathology, Vol. 96, No. 2, 01.01.1991, p. 177-183.

Research output: Contribution to journalArticle

Nakamine, H. ; Masih, A. S. ; Strobach, R. S. ; Duggan, M. J. ; Bast, M. A. ; Armitage, James Olen ; Weisenburger, D. D. / Immunoblastic lymphoma with abundant clear cytoplasm : A comparative study of B- and T-cell types. In: American journal of clinical pathology. 1991 ; Vol. 96, No. 2. pp. 177-183.
@article{2c62782f085e4e8594c9e122768aab85,
title = "Immunoblastic lymphoma with abundant clear cytoplasm: A comparative study of B- and T-cell types",
abstract = "The morphologic, phenotypic, molecular genetic, and clinical features of 34 cases of clear-cell immunoblastic lymphoma (IBLC) are described. Sixteen cases were of B-cell type (IBLC-B) and 18 cases were of T-cell type (IBLC-T). There were no significant differences in the morphologic characteristics of the neoplastic cells in the two types, although IBLC-B was less likely to be polymorphic than IBLC-T. Interfollicular proliferation, a higher mitotic rate, infiltration by eosinophils, and an increase in capillary-sized blood vessels were also features of IBLC-T, whereas necrosis and fibrosis were more extensive in IBLC-B. Patients with IBLC-B were predominantly female, whereas those with IBLC-T were predominantly male. The mean age was 62 years for those with IBLC-B and 46 years for those with IBLC-T. Patients with IBLC-B usually had lower-stage disease, but there was no significant difference in survival rate between those with IBLC-B and those with IBLC-T. Although most cases of IBLC have been considered to be of peripheral T-cell origin, the authors conclude that IBLC-B is more common than previously considered and that clear-cell morphologic characteristics are not a reliable indicator of T-cell type.",
keywords = "B-cell lymphoma, Clear cell, Immunoblastic lymphoma, Non-Hodgkin's lymphoma, Peripheral T-cell lymphoma",
author = "H. Nakamine and Masih, {A. S.} and Strobach, {R. S.} and Duggan, {M. J.} and Bast, {M. A.} and Armitage, {James Olen} and Weisenburger, {D. D.}",
year = "1991",
month = "1",
day = "1",
doi = "10.1093/ajcp/96.2.177",
language = "English (US)",
volume = "96",
pages = "177--183",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "2",

}

TY - JOUR

T1 - Immunoblastic lymphoma with abundant clear cytoplasm

T2 - A comparative study of B- and T-cell types

AU - Nakamine, H.

AU - Masih, A. S.

AU - Strobach, R. S.

AU - Duggan, M. J.

AU - Bast, M. A.

AU - Armitage, James Olen

AU - Weisenburger, D. D.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - The morphologic, phenotypic, molecular genetic, and clinical features of 34 cases of clear-cell immunoblastic lymphoma (IBLC) are described. Sixteen cases were of B-cell type (IBLC-B) and 18 cases were of T-cell type (IBLC-T). There were no significant differences in the morphologic characteristics of the neoplastic cells in the two types, although IBLC-B was less likely to be polymorphic than IBLC-T. Interfollicular proliferation, a higher mitotic rate, infiltration by eosinophils, and an increase in capillary-sized blood vessels were also features of IBLC-T, whereas necrosis and fibrosis were more extensive in IBLC-B. Patients with IBLC-B were predominantly female, whereas those with IBLC-T were predominantly male. The mean age was 62 years for those with IBLC-B and 46 years for those with IBLC-T. Patients with IBLC-B usually had lower-stage disease, but there was no significant difference in survival rate between those with IBLC-B and those with IBLC-T. Although most cases of IBLC have been considered to be of peripheral T-cell origin, the authors conclude that IBLC-B is more common than previously considered and that clear-cell morphologic characteristics are not a reliable indicator of T-cell type.

AB - The morphologic, phenotypic, molecular genetic, and clinical features of 34 cases of clear-cell immunoblastic lymphoma (IBLC) are described. Sixteen cases were of B-cell type (IBLC-B) and 18 cases were of T-cell type (IBLC-T). There were no significant differences in the morphologic characteristics of the neoplastic cells in the two types, although IBLC-B was less likely to be polymorphic than IBLC-T. Interfollicular proliferation, a higher mitotic rate, infiltration by eosinophils, and an increase in capillary-sized blood vessels were also features of IBLC-T, whereas necrosis and fibrosis were more extensive in IBLC-B. Patients with IBLC-B were predominantly female, whereas those with IBLC-T were predominantly male. The mean age was 62 years for those with IBLC-B and 46 years for those with IBLC-T. Patients with IBLC-B usually had lower-stage disease, but there was no significant difference in survival rate between those with IBLC-B and those with IBLC-T. Although most cases of IBLC have been considered to be of peripheral T-cell origin, the authors conclude that IBLC-B is more common than previously considered and that clear-cell morphologic characteristics are not a reliable indicator of T-cell type.

KW - B-cell lymphoma

KW - Clear cell

KW - Immunoblastic lymphoma

KW - Non-Hodgkin's lymphoma

KW - Peripheral T-cell lymphoma

UR - http://www.scopus.com/inward/record.url?scp=0026335122&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026335122&partnerID=8YFLogxK

U2 - 10.1093/ajcp/96.2.177

DO - 10.1093/ajcp/96.2.177

M3 - Article

VL - 96

SP - 177

EP - 183

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 2

ER -