20 Citations (Scopus)

Abstract

Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Currently, no curative treatments or treatments that interdict disease progression are available. Over the past decade, immunization strategies were developed in our laboratories to combat disease progression. These strategies were developed in laboratory and animal models of human disease. Induction of humoral immune responses can be elicited against misfolded protein aggregates. Robust cellmediated immunity against nitrated misfolded protein(s) accelerates disease progression through effector T cell responses that facilitate neuronal death. We propose that shifting the balance between effector and regulatory T cell activity can attenuate neurotoxic inflammatory events. We now summarize our works that support immune regulation in PD with the singular goal of restoring homeostatic glial responses. New methods to optimize immunization schemes and measure their clinical efficacy are discussed.

Original languageEnglish (US)
Pages (from-to)S218-S221
JournalParkinsonism and Related Disorders
Volume18
Issue numberSUPPL. 1
StatePublished - Jan 2012

Fingerprint

Parkinson Disease
Disease Progression
Immunization
Movement Disorders
Regulatory T-Lymphocytes
Humoral Immunity
Neuroglia
Neurodegenerative Diseases
Immunity
Animal Models
T-Lymphocytes
Therapeutics
Proteins
Protein Aggregates

Keywords

  • Effector T cells
  • Immunity
  • Immunization
  • Microglia
  • Neuroprotection
  • Regulatory T cells

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Immunization strategies for Parkinson's disease. / Ha, Duy; Stone, David K.; Mosley, R Lee; Gendelman, Howard Eliot.

In: Parkinsonism and Related Disorders, Vol. 18, No. SUPPL. 1, 01.2012, p. S218-S221.

Research output: Contribution to journalArticle

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AU - Ha, Duy

AU - Stone, David K.

AU - Mosley, R Lee

AU - Gendelman, Howard Eliot

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AB - Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Currently, no curative treatments or treatments that interdict disease progression are available. Over the past decade, immunization strategies were developed in our laboratories to combat disease progression. These strategies were developed in laboratory and animal models of human disease. Induction of humoral immune responses can be elicited against misfolded protein aggregates. Robust cellmediated immunity against nitrated misfolded protein(s) accelerates disease progression through effector T cell responses that facilitate neuronal death. We propose that shifting the balance between effector and regulatory T cell activity can attenuate neurotoxic inflammatory events. We now summarize our works that support immune regulation in PD with the singular goal of restoring homeostatic glial responses. New methods to optimize immunization schemes and measure their clinical efficacy are discussed.

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