Immune transcriptome alterations in the temporal cortex of subjects with autism

Krassimira Garbett, Philip J. Ebert, Amanda Mitchell, Carla Lintas, Barbara Manzi, Karoly Mirnics, Antonio M. Persico

Research output: Contribution to journalArticle

231 Citations (Scopus)

Abstract

Autism is a severe disorder that involves both genetic and environmental factors. Expression profiling of the superior temporal gyrus of six autistic subjects and matched controls revealed increased transcript levels of many immune system-related genes. We also noticed changes in transcripts related to cell communication, differentiation, cell cycle regulation and chaperone systems. Critical expression changes were confirmed by qPCR (BCL6, CHI3L1, CYR61, IFI16, IFITM3, MAP2K3, PTDSR, RFX4, SPP1, RELN, NOTCH2, RIT1, SFN, GADD45B, HSPA6, HSPB8 and SERPINH1). Overall, these expression patterns appear to be more associated with the late recovery phase of autoimmune brain disorders, than with the innate immune response characteristic of neurodegenerative diseases. Moreover, a variance-based analysis revealed much greater transcript variability in brains from autistic subjects compared to the control group, suggesting that these genes may represent autism susceptibility genes and should be assessed in follow-up genetic studies.

Original languageEnglish (US)
Pages (from-to)303-311
Number of pages9
JournalNeurobiology of Disease
Volume30
Issue number3
DOIs
StatePublished - Jun 1 2008

Fingerprint

Temporal Lobe
Autistic Disorder
Transcriptome
Genes
Brain Diseases
Innate Immunity
Cell Communication
Neurodegenerative Diseases
Cell Differentiation
Immune System
Analysis of Variance
Cell Cycle
Control Groups
Brain

Keywords

  • Autism
  • DNA microarray
  • Gene expression
  • Post mortem
  • Temporal cortex
  • Transcriptome
  • qPCR

ASJC Scopus subject areas

  • Neurology

Cite this

Garbett, K., Ebert, P. J., Mitchell, A., Lintas, C., Manzi, B., Mirnics, K., & Persico, A. M. (2008). Immune transcriptome alterations in the temporal cortex of subjects with autism. Neurobiology of Disease, 30(3), 303-311. https://doi.org/10.1016/j.nbd.2008.01.012

Immune transcriptome alterations in the temporal cortex of subjects with autism. / Garbett, Krassimira; Ebert, Philip J.; Mitchell, Amanda; Lintas, Carla; Manzi, Barbara; Mirnics, Karoly; Persico, Antonio M.

In: Neurobiology of Disease, Vol. 30, No. 3, 01.06.2008, p. 303-311.

Research output: Contribution to journalArticle

Garbett, K, Ebert, PJ, Mitchell, A, Lintas, C, Manzi, B, Mirnics, K & Persico, AM 2008, 'Immune transcriptome alterations in the temporal cortex of subjects with autism', Neurobiology of Disease, vol. 30, no. 3, pp. 303-311. https://doi.org/10.1016/j.nbd.2008.01.012
Garbett, Krassimira ; Ebert, Philip J. ; Mitchell, Amanda ; Lintas, Carla ; Manzi, Barbara ; Mirnics, Karoly ; Persico, Antonio M. / Immune transcriptome alterations in the temporal cortex of subjects with autism. In: Neurobiology of Disease. 2008 ; Vol. 30, No. 3. pp. 303-311.
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