Immune recovery uveitis in patients with AIDS and cytomegalovirus retinitis after highly active antiretroviral therapy

Quan Dong Nguyen, John H. Kempen, Stephen G. Bolton, James P. Dunn, Douglas A. Jabs

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

PURPOSE: To estimate the incidence and describe the characteristics of immune recovery uveitis in patients with acquired immunodeficiency syndrome (AIDS) and cytomegalovirus retinitis treated with highly active antiretroviral therapy. METHODS: The records of all patients with AIDS and cytomegalovirus retinitis from 1995 to 1998 seen at the AIDS Ophthalmology Service of the Johns Hopkins Medical Institutions were reviewed. Eighty-two patients with cytomegalovirus retinitis treated with highly active antiretroviral therapy were identified. Thirty-three patients (40.2%) were classified as responders to highly active antiretroviral therapy, defined as an increase in CD4+ T-cell count by 50 cells/μL or more to a level of 100 cells/μL or more. RESULTS: Immune recovery uveitis occurred in six patients. Among the 33 patients with an immunologic response to highly active antiretroviral therapy, the incidence rate of immune recovery uveitis was 0.109/person-year. Ocular complications associated with immune recovery uveitis included cystoid macular edema (four patients), epiretinal membranes (two patients), and optic disk neovascularization (one patient). CONCLUSIONS: Immune recovery uveitis was uncommon in our population but may have vision-impairing complications. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)634-639
Number of pages6
JournalAmerican Journal of Ophthalmology
Volume129
Issue number5
DOIs
StatePublished - May 1 2000

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Cytomegalovirus Retinitis
Uveitis
Highly Active Antiretroviral Therapy
Acquired Immunodeficiency Syndrome
Epiretinal Membrane
Macular Edema
Incidence
Optic Disk
Ophthalmology
CD4 Lymphocyte Count
T-Lymphocytes

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Immune recovery uveitis in patients with AIDS and cytomegalovirus retinitis after highly active antiretroviral therapy. / Nguyen, Quan Dong; Kempen, John H.; Bolton, Stephen G.; Dunn, James P.; Jabs, Douglas A.

In: American Journal of Ophthalmology, Vol. 129, No. 5, 01.05.2000, p. 634-639.

Research output: Contribution to journalArticle

Nguyen, Quan Dong ; Kempen, John H. ; Bolton, Stephen G. ; Dunn, James P. ; Jabs, Douglas A. / Immune recovery uveitis in patients with AIDS and cytomegalovirus retinitis after highly active antiretroviral therapy. In: American Journal of Ophthalmology. 2000 ; Vol. 129, No. 5. pp. 634-639.
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