Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion

Xinrui Li, Kaihong Su, Chuanyi Ji, Alexander J. Szalai, Jianming Wu, Yan Zhang, Tong Zhou, Robert P. Kimberly, Jeffrey C. Edberg

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

TNF ligand superfamily member 13B (B lymphocyte stimulator (BLyS), B cell activating factor (BAFF)) promotes primary B cell proliferation and Ig production. While the soluble form of BLyS/BAFF is thought to be the primary biologically active form, little is known about the regulation of its cleavage and processing. We provide evidence that Fcγ receptor cross-linking triggers a rapid release of soluble, biologically active BLyS/BAFF from myeloid cells. Surprisingly, this function is primarily mediated by FcγRI, but not FcγRIIa as defined by specific mAb, and can be initiated by both IgG and C reactive protein as ligands. The generation of a B cell proliferation and survival factor by both innate and adaptive immune opsonins through engagement of an Fcγ receptor, which can also enhance Ag uptake and presentation, provides a unique opportunity to facilitate Ab production. These results provide a mechanism by which Fcγ receptors can elevate circulating BLyS levels and promote autoantibody production in immune complex-mediated autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)1012-1018
Number of pages7
JournalJournal of Immunology
Volume181
Issue number2
DOIs
StatePublished - Jul 15 2008

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B-Cell Activating Factor
Opsonin Proteins
Fc Receptors
B-Lymphocytes
Cell Proliferation
Ligands
Myeloid Cells
Antigen-Antibody Complex
C-Reactive Protein
Autoantibodies
Autoimmune Diseases
Cell Survival
Immunoglobulin G

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Li, X., Su, K., Ji, C., Szalai, A. J., Wu, J., Zhang, Y., ... Edberg, J. C. (2008). Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion. Journal of Immunology, 181(2), 1012-1018. https://doi.org/10.4049/jimmunol.181.2.1012

Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion. / Li, Xinrui; Su, Kaihong; Ji, Chuanyi; Szalai, Alexander J.; Wu, Jianming; Zhang, Yan; Zhou, Tong; Kimberly, Robert P.; Edberg, Jeffrey C.

In: Journal of Immunology, Vol. 181, No. 2, 15.07.2008, p. 1012-1018.

Research output: Contribution to journalArticle

Li, X, Su, K, Ji, C, Szalai, AJ, Wu, J, Zhang, Y, Zhou, T, Kimberly, RP & Edberg, JC 2008, 'Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion', Journal of Immunology, vol. 181, no. 2, pp. 1012-1018. https://doi.org/10.4049/jimmunol.181.2.1012
Li, Xinrui ; Su, Kaihong ; Ji, Chuanyi ; Szalai, Alexander J. ; Wu, Jianming ; Zhang, Yan ; Zhou, Tong ; Kimberly, Robert P. ; Edberg, Jeffrey C. / Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion. In: Journal of Immunology. 2008 ; Vol. 181, No. 2. pp. 1012-1018.
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