Immune evasion by pathogens of bovine respiratory disease complex

Subramaniam Srikumaran, Clayton L Kelling, Aruna Ambagala

Research output: Contribution to journalReview article

60 Citations (Scopus)

Abstract

Bovine respiratory tract disease is a multi-factorial disease complex involving several viruses and bacteria. Viruses that play prominent roles in causing the bovine respiratory disease complex include bovine herpesvirus-1, bovine respiratory syncytial virus, bovine viral diarrhea virus and parinfluenza-3 virus. Bacteria that play prominent roles in this disease complex are Mannheimia haemolytica and Mycoplasma bovis. Other bacteria that infect the bovine respiratory tract of cattle are Histophilus (Haemophilus) somni and Pasteurella multocida. Frequently, severe respiratory tract disease in cattle is associated with concurrent infections of these pathogens. Like other pathogens, the viral and bacterial pathogens of this disease complex have co-evolved with their hosts over millions of years. As much as the hosts have diversified and fine-tuned the components of their immune system, the pathogens have also evolved diverse and sophisticated strategies to evade the host immune responses. These pathogens have developed intricate mechanisms to thwart both the innate and adaptive arms of the immune responses of their hosts. This review presents an overview of the strategies by which the pathogens suppress host immune responses, as well as the strategies by which the pathogens modify themselves or their locations in the host to evade host immune responses. These immune evasion strategies likely contribute to the failure of currently-available vaccines to provide complete protection to cattle against these pathogens.

Original languageEnglish (US)
Pages (from-to)215-229
Number of pages15
JournalAnimal Health Research Reviews
Volume8
Issue number2
DOIs
StatePublished - Jan 1 1996

Fingerprint

immune evasion
bovine respiratory disease
pathogens
immune response
cattle
viruses
respiratory tract diseases
bacteria
Haemophilus
Mycoplasma bovis
Bovine respiratory syncytial virus
Bovine herpesvirus 1
Mannheimia haemolytica
Bovine viral diarrhea virus
Pasteurella multocida
mixed infection
respiratory system
immune system
vaccines

Keywords

  • bovine respiratory disease complex
  • immune evasion
  • pathogens

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Immune evasion by pathogens of bovine respiratory disease complex. / Srikumaran, Subramaniam; Kelling, Clayton L; Ambagala, Aruna.

In: Animal Health Research Reviews, Vol. 8, No. 2, 01.01.1996, p. 215-229.

Research output: Contribution to journalReview article

Srikumaran, Subramaniam ; Kelling, Clayton L ; Ambagala, Aruna. / Immune evasion by pathogens of bovine respiratory disease complex. In: Animal Health Research Reviews. 1996 ; Vol. 8, No. 2. pp. 215-229.
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