Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing mice

Kenneth F. May, Kenneth Lute, Ergun Kocak, Shahab Abdessalam, Lijie Yin, Ou Li, Zhen Guan, Gary Philips, Pan Zheng, Yang Liu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The impact of timing of antigen introduction into fetus and neonates leads to the suggestion that pre-existing antigens are tolerogenic to immunocompetent cells generated thereafter. This hypothesis predicts that in patients with cancer who are undergoing bone marrow transplantation, newly produced T cells with specificity for pre-existing tumor cells will be inactivated by the tumor antigens in the host. Because the effect of tumor cells on developing cancer-reactive T cells has not been investigated, we set out to systematically analyze the impact of tumor cells in the periphery on the development of tumor-reactive T cells in the thymus and their immunocompetence in the periphery. Our data demonstrate that in the host in which a tumor is established in the periphery, the cancer-reactive T cells develop normally, remain fully immunocompetent, become activated in the periphery, and cause regression of large established tumors. The immunocompetence of T cells generated in an antigen-bearing host is also confirmed in a skin graft transplantation model.

Original languageEnglish (US)
Pages (from-to)253-258
Number of pages6
JournalBlood
Volume109
Issue number1
DOIs
StatePublished - Jan 1 2007

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Bearings (structural)
T-cells
Mental Competency
Tumors
T-Lymphocytes
Neoplasms
Cells
Antigens
Immunocompetence
Transplantation (surgical)
Thymus
Neoplasm Antigens
Grafts
T-Cell Antigen Receptor Specificity
Skin
Bone
Skin Transplantation
Bone Marrow Transplantation
Thymus Gland
Fetus

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing mice. / May, Kenneth F.; Lute, Kenneth; Kocak, Ergun; Abdessalam, Shahab; Yin, Lijie; Li, Ou; Guan, Zhen; Philips, Gary; Zheng, Pan; Liu, Yang.

In: Blood, Vol. 109, No. 1, 01.01.2007, p. 253-258.

Research output: Contribution to journalArticle

May, KF, Lute, K, Kocak, E, Abdessalam, S, Yin, L, Li, O, Guan, Z, Philips, G, Zheng, P & Liu, Y 2007, 'Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing mice', Blood, vol. 109, no. 1, pp. 253-258. https://doi.org/10.1182/blood-2006-01-031278
May, Kenneth F. ; Lute, Kenneth ; Kocak, Ergun ; Abdessalam, Shahab ; Yin, Lijie ; Li, Ou ; Guan, Zhen ; Philips, Gary ; Zheng, Pan ; Liu, Yang. / Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing mice. In: Blood. 2007 ; Vol. 109, No. 1. pp. 253-258.
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