Immune cell infiltration of primary and metastatic lesions

Mechanisms and clinical impact

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

The infiltration of tumors and their metastases by hematopoietic cells can contribute both positively and negatively to tumor growth, invasion, and patient outcomes. These differing outcomes are associated with both tumor heterogeneity and the diversity of leukocytes infiltrating neoplastic lesions. Tumors infiltration by histiocytes (macrophages and dendritic cells (DCs)) is associated with poor clinical outcomes, although infiltration by a subset of DCs is related to improved outcomes. T-cell infiltration of tumors and metastases are surrogates for positive outcomes, although subset analysis suggests that not all infiltrating T-cells have this potential. Overall, tumor infiltration by CD8+ T-cells is associated with a positive outcome, while the frequency of infiltrating CD4+ cells may be a negative predictor. In addition to tumor infiltration by macrophages and T-cells, recent studies have shown that myeloid-derived suppressor cells (MDSCs), also infiltrate tumors, inhibiting T-cell and DC number and function and facilitate tumor growth, angiogenesis, and metastasis. In summary, hematopoietic cell infiltration of tumors can regulate tumor progression and provide a useful diagnostic surrogate. Further, strategies focused on the manipulation of cellular infiltration via cellular, gene and molecular immunotherapies have the potential to provide a novel target for adjuvant therapy.

Original languageEnglish (US)
Pages (from-to)131-138
Number of pages8
JournalSeminars in Cancer Biology
Volume21
Issue number2
DOIs
StatePublished - Apr 1 2011

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Neoplasms
T-Lymphocytes
Dendritic Cells
Neoplasm Metastasis
Macrophages
Histiocytes
Growth
Immunotherapy
Leukocytes
Cell Count
Genes
Therapeutics

Keywords

  • Macrophages
  • Metastasis
  • Microenvironment
  • Myeloid derived suppressor cells

ASJC Scopus subject areas

  • Cancer Research

Cite this

Immune cell infiltration of primary and metastatic lesions : Mechanisms and clinical impact. / Talmadge, James E.

In: Seminars in Cancer Biology, Vol. 21, No. 2, 01.04.2011, p. 131-138.

Research output: Contribution to journalReview article

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