Abstract

Damage to DNA by dopamine quinone and/or catechol estrogen quinones may play a significant role in the initiation of Parkinson's disease (PD). Depurinating estrogenDNA adducts are shed from cells and excreted in urine. The aim of this study was to discover whether higher levels of estrogenDNA adducts are associated with PD. Forty estrogen metabolites, conjugates, and DNA adducts were analyzed in urine samples from 20 PD cases and 40 matched controls by using ultra performance liquid chromatography/tandem mass spectrometry. The levels of adducts in cases versus controls (P < 0.005) suggest that unbalanced estrogen metabolism could play a causal role in the initiation of PD.

Original languageEnglish (US)
Pages (from-to)434-444
Number of pages11
JournalBiomarkers
Volume16
Issue number5
DOIs
StatePublished - Aug 1 2011

Fingerprint

Metabolism
Parkinson Disease
Brain
Estrogens
Catechol Estrogens
Urine
Quinones
DNA Adducts
Liquid chromatography
Metabolites
Tandem Mass Spectrometry
Liquid Chromatography
DNA Damage
Mass spectrometry
DNA

Keywords

  • Catechol estrogen quinones
  • Depurinating estrogenDNA adducts
  • UPLC-MS/MS
  • Urinary biomarkers

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

Imbalanced estrogen metabolism in the brain : Possible relevance to the etiology of Parkinson's disease. / Gaikwad, Nilesh W.; Murman, Daniel L; Beseler, Cheryl L.; Zahid, Muhammad; Rogan, Eleanor G; Cavalieri, Ercole.

In: Biomarkers, Vol. 16, No. 5, 01.08.2011, p. 434-444.

Research output: Contribution to journalArticle

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