Image-guided tumor surgery

will there be a role for fluorescent nanoparticles?

Tanner K. Hill, Aaron M Mohs

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Image-guided surgery (IGS) using fluorescent nanoparticles (NPs) has the potential to substantially impact patient treatment. The use of fluorescence imaging provides surgeons with real-time feedback on the location of diseased tissue using safe, low-cost imaging agents and instrumentation. Fluorescent NPs are likely to play a role as they are capable of taking advantage of the enhanced permeability and retention (EPR) effect and can be modified to avoid clearance, increase circulation time, and specifically target tumors. Clinical trials of IGS using the FDA-approved fluorophores indocyanine green and methylene blue have already shown preliminary successes, and incorporation of fluorescent NPs will likely improve detection by providing higher signal to background ratio and reducing false-positive rates through active targeting. Preclinical development of fluorescent NP formulations is advancing rapidly, with strategies ranging from passive targeting to active targeting of cell surface receptors, creating pH-responsive NPs, and increasing cell uptake through cleavable proteins. This collective effort could lead to clinical trials using fluorescent NPs in the near future. WIREs Nanomed Nanobiotechnol 2016, 8:498–511. doi: 10.1002/wnan.1381. For further resources related to this article, please visit the WIREs website.

Original languageEnglish (US)
Pages (from-to)498-511
Number of pages14
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Volume8
Issue number4
DOIs
StatePublished - Jul 1 2016

Fingerprint

Computer-Assisted Surgery
Nanoparticles
Surgery
Tumors
Neoplasms
Clinical Trials
Patient treatment
Imaging techniques
Indocyanine Green
Fluorophores
Methylene Blue
Optical Imaging
Cell Surface Receptors
Websites
Permeability
Fluorescence
Tissue
Proteins
Feedback
Costs and Cost Analysis

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)

Cite this

Image-guided tumor surgery : will there be a role for fluorescent nanoparticles? / Hill, Tanner K.; Mohs, Aaron M.

In: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, Vol. 8, No. 4, 01.07.2016, p. 498-511.

Research output: Contribution to journalReview article

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