IL‐1 in gingival crevicular fluid following closed root planing and papillary flap debridement

Richard A Reinhardt, M. P. Masada, G. K. Johnson, L. M. DuBois, G. J. Seymour, A. C. Allison

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Abstract Interleukin (IL)‐1 alpha and beta are cytokines which can mediate inflammatory, bone resorbing. and reparative effects in the periodontium, but few longitudinal data exist exploring their role following periodontal therapy. This study examined gingival crevicular fluid (GCF) concentrations of IL‐1 alpha and TL‐1 beta at sites with shallow sulci (SS) or inflamed moderate/advanced pockets (M/AP) before and 6 months after treatment with closed scaling/root planing (SC/RP) or papillary flap debridement (PFD), all in the same subject (n=14 patients). No significant differences were noted in IL‐1 alpha or beta concentrations (determined with two‐site enzyme‐linked immunosorbent assays) between SS and M/AP sites at baseline. While both therapies improved clinical parameters of periodontal disease, IL‐1 alpha concentration increased significantly (p<0.05) in M/AP‐PFD sites 6 months after treatment, but were unchanged in other groups. IL‐1 beta concentrations were numerically lower after therapy, except for a significant increase (P<0.05) in M/AP‐PFD sites. These data suggest that surgical wound healing in an inflamed, plaque‐infected site (M/AP‐PFD) results in prolonged production of IL‐1, which may be a reflection of the extent of tissue trauma and delayed wound healing. In spite of increased IL‐1 levels, these sites demonstrated significant short‐term improvement in clinical attachment level (+ 1.8 mm, p<0.001) postoperatively.

Original languageEnglish (US)
Pages (from-to)514-519
Number of pages6
JournalJournal of Clinical Periodontology
Volume20
Issue number7
DOIs
StatePublished - Jan 1 1993

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Root Planing
Gingival Crevicular Fluid
Debridement
Wound Healing
Therapeutics
Periodontium
Immunosorbents
Interleukin-1alpha
Periodontal Diseases
Interleukin-1beta
Cytokines
Bone and Bones
Wounds and Injuries

Keywords

  • IL‐1 beta: gingival crevicular fluid (GCF)
  • interleukin (IL)‐1 alpha
  • papillary flap debridement
  • root planing
  • wound healing

ASJC Scopus subject areas

  • Periodontics

Cite this

IL‐1 in gingival crevicular fluid following closed root planing and papillary flap debridement. / Reinhardt, Richard A; Masada, M. P.; Johnson, G. K.; DuBois, L. M.; Seymour, G. J.; Allison, A. C.

In: Journal of Clinical Periodontology, Vol. 20, No. 7, 01.01.1993, p. 514-519.

Research output: Contribution to journalArticle

Reinhardt, Richard A ; Masada, M. P. ; Johnson, G. K. ; DuBois, L. M. ; Seymour, G. J. ; Allison, A. C. / IL‐1 in gingival crevicular fluid following closed root planing and papillary flap debridement. In: Journal of Clinical Periodontology. 1993 ; Vol. 20, No. 7. pp. 514-519.
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AB - Abstract Interleukin (IL)‐1 alpha and beta are cytokines which can mediate inflammatory, bone resorbing. and reparative effects in the periodontium, but few longitudinal data exist exploring their role following periodontal therapy. This study examined gingival crevicular fluid (GCF) concentrations of IL‐1 alpha and TL‐1 beta at sites with shallow sulci (SS) or inflamed moderate/advanced pockets (M/AP) before and 6 months after treatment with closed scaling/root planing (SC/RP) or papillary flap debridement (PFD), all in the same subject (n=14 patients). No significant differences were noted in IL‐1 alpha or beta concentrations (determined with two‐site enzyme‐linked immunosorbent assays) between SS and M/AP sites at baseline. While both therapies improved clinical parameters of periodontal disease, IL‐1 alpha concentration increased significantly (p<0.05) in M/AP‐PFD sites 6 months after treatment, but were unchanged in other groups. IL‐1 beta concentrations were numerically lower after therapy, except for a significant increase (P<0.05) in M/AP‐PFD sites. These data suggest that surgical wound healing in an inflamed, plaque‐infected site (M/AP‐PFD) results in prolonged production of IL‐1, which may be a reflection of the extent of tissue trauma and delayed wound healing. In spite of increased IL‐1 levels, these sites demonstrated significant short‐term improvement in clinical attachment level (+ 1.8 mm, p<0.001) postoperatively.

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