IL-8 expression in malignant melanoma: Implications in growth and metastasis

Rakesh K Singh, M. L. Varney

Research output: Contribution to journalReview article

73 Citations (Scopus)

Abstract

This review article has described briefly studies supporting the concept that IL-8 expression and its regulation by inflammatory cytokines like IL-1 may play an important role in controlling the phenotypes associated with melanoma progression and metastasis. It is clear from the experiments presented here that IL-8 is an important autocrine multifunctional cytokine that modulates melanoma/cell proliferation, migration by induction of extracellular matrix degradation enzymes and induces neovascularization, all of which are critical for melanoma growth and metastasis. In addition, their expression in melanoma tumor specimens suggests an association between IL-8 expression and tumor aggressiveness. Further, inflammatory cytokines produced by either tumor cells or stromal cells may regulate IL-8 expression, which can control melanoma growth and enhance our current knowledge regarding melanoma progression and metastasis. Understanding these events and their significance will allow us to design novel therapeutic approaches for treatment of melanoma.

Original languageEnglish (US)
Pages (from-to)843-849
Number of pages7
JournalHistology and Histopathology
Volume15
Issue number3
StatePublished - Aug 9 2000

Fingerprint

Interleukin-8
Melanoma
Neoplasm Metastasis
Growth
Cytokines
Neoplasms
Stromal Cells
Interleukin-1
Cell Movement
Extracellular Matrix
Cell Proliferation
Phenotype
Enzymes

Keywords

  • IL-8
  • Melanoma
  • Metastasis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

IL-8 expression in malignant melanoma : Implications in growth and metastasis. / Singh, Rakesh K; Varney, M. L.

In: Histology and Histopathology, Vol. 15, No. 3, 09.08.2000, p. 843-849.

Research output: Contribution to journalReview article

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