IL-6 and its receptors in coronary artery disease and acute myocardial infarction

Daniel R Anderson, Joseph T. Poterucha, Ted R Mikuls, Michael J. Duryee, Robert P. Garvin, Lynell Warren Klassen, Scott W. Shurmur, Geoffrey Milton Thiele

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Biomarkers such as interleukin-6 (IL-6), soluble interleukin-6 receptor (sIL-6R), and high sensitive C-reactive protein (hsCRP) have been reported to be elevated in acute myocardial infarction (AMI). The aim of this study is to determine the relationship between these markers during AMI, as well as their relationship to clinical parameters in an effort to discern their predictive potential in cardiac events.Serum was collected from 73 patients with; AMI, stable coronary artery disease (CAD), and controls during cardiac catheterization. Biomarker levels were determined and correlated with clinical data. IL-6 (11.75. pg/ml, P<. 0.05) and sIL-6R (41,340. pg/ml, P=. 0.05) were elevated in AMI compared with CAD and controls. At presentation, hsCRP was elevated in AMI patients (4.69. mg/L) compared to controls (2.69. mg/L, P<. 0.05); however, there was a significant decrease in hsCRP between AMI (4.69. mg/L) and CAD patients (7.4. mg/L, P<. 0.05). After 24. h post-AMI hsCRP levels were increased compared to stable CAD (60.46. mg/L, P<. 0.05) and were preceded by increased IL-6 at presentation. Soluble Gp130 (sGp130) showed no significant change between AMI, CAD, and control patients. However, sGp130 positively correlated with peak troponin in AMI (. R=. 0.587, P<. 0.01), and negatively correlated with previous AMI (. R=. -0.382, P<. 0.05). Circulating monocyte mRNA expression isolated from selected AMI patients showed an increase in IL-6 mRNA (5.28-fold, P<. 0.01) and a decrease in both IL-6R (0.374-fold, P<. 0.01) and sGp130 mRNA (0.38-fold, P<. 0.01) as compared to CAD and controls.Results demonstrate that IL-6 and sIL-6R are associated with AMI and cardiac injury. These data support the hypothesis that trans-IL-6 receptor binding may alter intracellular signaling, and blocking of IL-6 receptor binding may be pathogenic in AMI. These data may be predictive of mechanism(s) by which plaques become unstable and rupture.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalCytokine
Volume62
Issue number3
DOIs
StatePublished - Jun 1 2013

Fingerprint

Interleukin-6 Receptors
Coronary Artery Disease
Cytokine Receptor gp130
Myocardial Infarction
Interleukin-6
C-Reactive Protein
Biomarkers
Messenger RNA
Troponin
Cardiac Catheterization
Rupture
Monocytes

Keywords

  • Acute coronary syndromes
  • Acute myocardial infarction
  • Glycoprotein 130
  • Interleukin 6
  • Soluble interleukin 6 receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

Cite this

IL-6 and its receptors in coronary artery disease and acute myocardial infarction. / Anderson, Daniel R; Poterucha, Joseph T.; Mikuls, Ted R; Duryee, Michael J.; Garvin, Robert P.; Klassen, Lynell Warren; Shurmur, Scott W.; Thiele, Geoffrey Milton.

In: Cytokine, Vol. 62, No. 3, 01.06.2013, p. 395-400.

Research output: Contribution to journalArticle

Anderson, Daniel R ; Poterucha, Joseph T. ; Mikuls, Ted R ; Duryee, Michael J. ; Garvin, Robert P. ; Klassen, Lynell Warren ; Shurmur, Scott W. ; Thiele, Geoffrey Milton. / IL-6 and its receptors in coronary artery disease and acute myocardial infarction. In: Cytokine. 2013 ; Vol. 62, No. 3. pp. 395-400.
@article{26d69d3ee4f34560a76142eef70d190f,
title = "IL-6 and its receptors in coronary artery disease and acute myocardial infarction",
abstract = "Biomarkers such as interleukin-6 (IL-6), soluble interleukin-6 receptor (sIL-6R), and high sensitive C-reactive protein (hsCRP) have been reported to be elevated in acute myocardial infarction (AMI). The aim of this study is to determine the relationship between these markers during AMI, as well as their relationship to clinical parameters in an effort to discern their predictive potential in cardiac events.Serum was collected from 73 patients with; AMI, stable coronary artery disease (CAD), and controls during cardiac catheterization. Biomarker levels were determined and correlated with clinical data. IL-6 (11.75. pg/ml, P<. 0.05) and sIL-6R (41,340. pg/ml, P=. 0.05) were elevated in AMI compared with CAD and controls. At presentation, hsCRP was elevated in AMI patients (4.69. mg/L) compared to controls (2.69. mg/L, P<. 0.05); however, there was a significant decrease in hsCRP between AMI (4.69. mg/L) and CAD patients (7.4. mg/L, P<. 0.05). After 24. h post-AMI hsCRP levels were increased compared to stable CAD (60.46. mg/L, P<. 0.05) and were preceded by increased IL-6 at presentation. Soluble Gp130 (sGp130) showed no significant change between AMI, CAD, and control patients. However, sGp130 positively correlated with peak troponin in AMI (. R=. 0.587, P<. 0.01), and negatively correlated with previous AMI (. R=. -0.382, P<. 0.05). Circulating monocyte mRNA expression isolated from selected AMI patients showed an increase in IL-6 mRNA (5.28-fold, P<. 0.01) and a decrease in both IL-6R (0.374-fold, P<. 0.01) and sGp130 mRNA (0.38-fold, P<. 0.01) as compared to CAD and controls.Results demonstrate that IL-6 and sIL-6R are associated with AMI and cardiac injury. These data support the hypothesis that trans-IL-6 receptor binding may alter intracellular signaling, and blocking of IL-6 receptor binding may be pathogenic in AMI. These data may be predictive of mechanism(s) by which plaques become unstable and rupture.",
keywords = "Acute coronary syndromes, Acute myocardial infarction, Glycoprotein 130, Interleukin 6, Soluble interleukin 6 receptor",
author = "Anderson, {Daniel R} and Poterucha, {Joseph T.} and Mikuls, {Ted R} and Duryee, {Michael J.} and Garvin, {Robert P.} and Klassen, {Lynell Warren} and Shurmur, {Scott W.} and Thiele, {Geoffrey Milton}",
year = "2013",
month = "6",
day = "1",
doi = "10.1016/j.cyto.2013.03.020",
language = "English (US)",
volume = "62",
pages = "395--400",
journal = "Cytokine",
issn = "1043-4666",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - IL-6 and its receptors in coronary artery disease and acute myocardial infarction

AU - Anderson, Daniel R

AU - Poterucha, Joseph T.

AU - Mikuls, Ted R

AU - Duryee, Michael J.

AU - Garvin, Robert P.

AU - Klassen, Lynell Warren

AU - Shurmur, Scott W.

AU - Thiele, Geoffrey Milton

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Biomarkers such as interleukin-6 (IL-6), soluble interleukin-6 receptor (sIL-6R), and high sensitive C-reactive protein (hsCRP) have been reported to be elevated in acute myocardial infarction (AMI). The aim of this study is to determine the relationship between these markers during AMI, as well as their relationship to clinical parameters in an effort to discern their predictive potential in cardiac events.Serum was collected from 73 patients with; AMI, stable coronary artery disease (CAD), and controls during cardiac catheterization. Biomarker levels were determined and correlated with clinical data. IL-6 (11.75. pg/ml, P<. 0.05) and sIL-6R (41,340. pg/ml, P=. 0.05) were elevated in AMI compared with CAD and controls. At presentation, hsCRP was elevated in AMI patients (4.69. mg/L) compared to controls (2.69. mg/L, P<. 0.05); however, there was a significant decrease in hsCRP between AMI (4.69. mg/L) and CAD patients (7.4. mg/L, P<. 0.05). After 24. h post-AMI hsCRP levels were increased compared to stable CAD (60.46. mg/L, P<. 0.05) and were preceded by increased IL-6 at presentation. Soluble Gp130 (sGp130) showed no significant change between AMI, CAD, and control patients. However, sGp130 positively correlated with peak troponin in AMI (. R=. 0.587, P<. 0.01), and negatively correlated with previous AMI (. R=. -0.382, P<. 0.05). Circulating monocyte mRNA expression isolated from selected AMI patients showed an increase in IL-6 mRNA (5.28-fold, P<. 0.01) and a decrease in both IL-6R (0.374-fold, P<. 0.01) and sGp130 mRNA (0.38-fold, P<. 0.01) as compared to CAD and controls.Results demonstrate that IL-6 and sIL-6R are associated with AMI and cardiac injury. These data support the hypothesis that trans-IL-6 receptor binding may alter intracellular signaling, and blocking of IL-6 receptor binding may be pathogenic in AMI. These data may be predictive of mechanism(s) by which plaques become unstable and rupture.

AB - Biomarkers such as interleukin-6 (IL-6), soluble interleukin-6 receptor (sIL-6R), and high sensitive C-reactive protein (hsCRP) have been reported to be elevated in acute myocardial infarction (AMI). The aim of this study is to determine the relationship between these markers during AMI, as well as their relationship to clinical parameters in an effort to discern their predictive potential in cardiac events.Serum was collected from 73 patients with; AMI, stable coronary artery disease (CAD), and controls during cardiac catheterization. Biomarker levels were determined and correlated with clinical data. IL-6 (11.75. pg/ml, P<. 0.05) and sIL-6R (41,340. pg/ml, P=. 0.05) were elevated in AMI compared with CAD and controls. At presentation, hsCRP was elevated in AMI patients (4.69. mg/L) compared to controls (2.69. mg/L, P<. 0.05); however, there was a significant decrease in hsCRP between AMI (4.69. mg/L) and CAD patients (7.4. mg/L, P<. 0.05). After 24. h post-AMI hsCRP levels were increased compared to stable CAD (60.46. mg/L, P<. 0.05) and were preceded by increased IL-6 at presentation. Soluble Gp130 (sGp130) showed no significant change between AMI, CAD, and control patients. However, sGp130 positively correlated with peak troponin in AMI (. R=. 0.587, P<. 0.01), and negatively correlated with previous AMI (. R=. -0.382, P<. 0.05). Circulating monocyte mRNA expression isolated from selected AMI patients showed an increase in IL-6 mRNA (5.28-fold, P<. 0.01) and a decrease in both IL-6R (0.374-fold, P<. 0.01) and sGp130 mRNA (0.38-fold, P<. 0.01) as compared to CAD and controls.Results demonstrate that IL-6 and sIL-6R are associated with AMI and cardiac injury. These data support the hypothesis that trans-IL-6 receptor binding may alter intracellular signaling, and blocking of IL-6 receptor binding may be pathogenic in AMI. These data may be predictive of mechanism(s) by which plaques become unstable and rupture.

KW - Acute coronary syndromes

KW - Acute myocardial infarction

KW - Glycoprotein 130

KW - Interleukin 6

KW - Soluble interleukin 6 receptor

UR - http://www.scopus.com/inward/record.url?scp=84877813326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877813326&partnerID=8YFLogxK

U2 - 10.1016/j.cyto.2013.03.020

DO - 10.1016/j.cyto.2013.03.020

M3 - Article

VL - 62

SP - 395

EP - 400

JO - Cytokine

JF - Cytokine

SN - 1043-4666

IS - 3

ER -