IL-23 in infections, inflammation, autoimmunity and cancer: Possible role in HIV-1 and AIDS

Govardhana Rao Yannam, Tanuja Gutti, Larisa Y. Poluektova

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

The growing family of interleukin (IL)-12-like cytokines produced by activated macrophages and dendritic cells became the important players in the control of infections, development of inflammation, autoimmunity and cancer. However, the role of one of them-heterodimer IL-23, which consists of IL12p40 and the unique p19 subunit in HIV-1 infection pathogenesis and progression to AIDS, represent special interest. We overviewed findings of IL-23 involvement in control of peripheral bacterial pathogens and opportunistic infection, central nervous system (CNS) viral infections and autoimmune disorders, and tumorogenesis, which potentially could be applicable to HIV-1 and AIDS.

Original languageEnglish (US)
Pages (from-to)95-112
Number of pages18
JournalJournal of Neuroimmune Pharmacology
Volume7
Issue number1
DOIs
StatePublished - Mar 1 2012

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Keywords

  • Autoimmune disorders
  • Bacterial infection
  • Central nervous system
  • HIV-1
  • IL-23
  • Interleukin-17

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

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