Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach

Guillermo de Anda-Jáuregui, Jesús Espinal-Enríquez, Junguk Hur, Sergio Antonio Alcalá-Corona, Lena Ruiz-Azuara, Enrique Hernández-Lemus

Research output: Contribution to journalArticle

Abstract

Casiopeinas are a group of copper-based compounds designed to be used as less toxic, more efficient chemotherapeutic agents. In this study, we analyzed the in vitro effects of Casiopeina II-gly on the expression of canonical biological pathways. Using microarray data from HeLa cell lines treated with Casiopeina II-gly, we identified biological pathways that are perturbed after treatment. We present a novel approach integrating pathway analysis and network theory: The Pathway Crosstalk Network. We constructed a network with deregulated pathways, featuring links between those pathways that crosstalk with each other. We identified modules grouping deregulated pathways that are functionally related. Through this approach, we were able to identify three features of Casiopeina treatment: (a) Perturbation of signaling pathways, related to induction of apoptosis; (b) perturbation of metabolic pathways, and (c) activation of immune responses. These findings can be useful to drive new experimental exploration on their role in adverse effects and efficacy of Casiopeinas.

Original languageEnglish (US)
Pages (from-to)127-132
Number of pages6
JournalComputational Biology and Chemistry
Volume78
DOIs
StatePublished - Feb 1 2019
Externally publishedYes

Fingerprint

Pharmacology
Crosstalk
Pathway
Target
Poisons
Circuit theory
Cell death
Microarrays
Metabolic Networks and Pathways
HeLa Cells
Telecommunication links
Copper
Chemical activation
Cells
Apoptosis
Cell Line
Perturbation
Signaling Pathways
casiopeina II-glycine
Immune Response

Keywords

  • Casiopeina
  • Copper
  • Genomics

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Organic Chemistry
  • Computational Mathematics

Cite this

de Anda-Jáuregui, G., Espinal-Enríquez, J., Hur, J., Alcalá-Corona, S. A., Ruiz-Azuara, L., & Hernández-Lemus, E. (2019). Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach. Computational Biology and Chemistry, 78, 127-132. https://doi.org/10.1016/j.compbiolchem.2018.11.021

Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach. / de Anda-Jáuregui, Guillermo; Espinal-Enríquez, Jesús; Hur, Junguk; Alcalá-Corona, Sergio Antonio; Ruiz-Azuara, Lena; Hernández-Lemus, Enrique.

In: Computational Biology and Chemistry, Vol. 78, 01.02.2019, p. 127-132.

Research output: Contribution to journalArticle

de Anda-Jáuregui, G, Espinal-Enríquez, J, Hur, J, Alcalá-Corona, SA, Ruiz-Azuara, L & Hernández-Lemus, E 2019, 'Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach' Computational Biology and Chemistry, vol. 78, pp. 127-132. https://doi.org/10.1016/j.compbiolchem.2018.11.021
de Anda-Jáuregui, Guillermo ; Espinal-Enríquez, Jesús ; Hur, Junguk ; Alcalá-Corona, Sergio Antonio ; Ruiz-Azuara, Lena ; Hernández-Lemus, Enrique. / Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach. In: Computational Biology and Chemistry. 2019 ; Vol. 78. pp. 127-132.
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