Identification of an antimalarial synthetic trioxolane drug development candidate

Jonathan L. Vennerstrom, Sarah Arbe-Barnes, Reto Brun, Susan A. Charman, Francis C.K. Chiu, Jacques Chollet, Yuxiang Dong, Arnulf Dorn, Daniel Hunziker, Hugues Matile, Kylie McIntosh, Maniyan Padmanilayam, Josefina Santo Tomas, Christian Scheurer, Bernard Scorneaux, Yuanqing Tang, Heinrich Urwyler, Sergio Wittlin, William H. Charman

Research output: Contribution to journalArticle

519 Citations (Scopus)

Abstract

The discovery of artemisinin more than 30 years ago provided a completely new antimalarial structural prototype; that is, a molecule with a pharmacophoric peroxide bond in a unique 1,2,4-trioxane heterocycle. Available evidence suggests that artemisinin and related peroxidic antimalarial drugs exert their parasiticidal activity subsequent to reductive activation by haem, released as a result of haemoglobin digestion by the malaria-causing parasite. This irreversible redox reaction produces carbon-centred free radicals, leading to alkylation of haem and proteins (enzymes), one of which-the sarcoplasmic- endoplasmic reticulum ATPase PfATP6 (ref. 7)-may be critical to parasite survival. Notably, there is no evidence of drug resistance to any member of the artemisinin family of drugs. The chemotherapy of malaria has benefited greatly from the semi-synthetic artemisinins artemether and artesunate as they rapidly reduce parasite burden, have good therapeutic indices and provide for successful treatment outcomes. However, as a drug class, the artemisinins suffer from chemical (semi-synthetic availability, purity and cost), biopharmaceutical (poor bioavailability and limiting pharmacokinetics) and treatment (non-compliance with long treatment regimens and recrudescence) issues that limit their therapeutic potential. Here we describe how a synthetic peroxide antimalarial drug development candidate was identified in a collaborative drug discovery project.

Original languageEnglish (US)
Pages (from-to)900-904
Number of pages5
JournalNature
Volume430
Issue number7002
DOIs
StatePublished - Aug 19 2004

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Antimalarials
Artemisinins
Parasites
Peroxides
Heme
Pharmaceutical Preparations
Malaria
Alkylation
Sarcoplasmic Reticulum
Drug Discovery
Therapeutics
Drug Resistance
Endoplasmic Reticulum
Biological Availability
Oxidation-Reduction
Free Radicals
Adenosine Triphosphatases
Digestion
Hemoglobins
Carbon

ASJC Scopus subject areas

  • General

Cite this

Vennerstrom, J. L., Arbe-Barnes, S., Brun, R., Charman, S. A., Chiu, F. C. K., Chollet, J., ... Charman, W. H. (2004). Identification of an antimalarial synthetic trioxolane drug development candidate. Nature, 430(7002), 900-904. https://doi.org/10.1038/nature02779

Identification of an antimalarial synthetic trioxolane drug development candidate. / Vennerstrom, Jonathan L.; Arbe-Barnes, Sarah; Brun, Reto; Charman, Susan A.; Chiu, Francis C.K.; Chollet, Jacques; Dong, Yuxiang; Dorn, Arnulf; Hunziker, Daniel; Matile, Hugues; McIntosh, Kylie; Padmanilayam, Maniyan; Santo Tomas, Josefina; Scheurer, Christian; Scorneaux, Bernard; Tang, Yuanqing; Urwyler, Heinrich; Wittlin, Sergio; Charman, William H.

In: Nature, Vol. 430, No. 7002, 19.08.2004, p. 900-904.

Research output: Contribution to journalArticle

Vennerstrom, JL, Arbe-Barnes, S, Brun, R, Charman, SA, Chiu, FCK, Chollet, J, Dong, Y, Dorn, A, Hunziker, D, Matile, H, McIntosh, K, Padmanilayam, M, Santo Tomas, J, Scheurer, C, Scorneaux, B, Tang, Y, Urwyler, H, Wittlin, S & Charman, WH 2004, 'Identification of an antimalarial synthetic trioxolane drug development candidate', Nature, vol. 430, no. 7002, pp. 900-904. https://doi.org/10.1038/nature02779
Vennerstrom JL, Arbe-Barnes S, Brun R, Charman SA, Chiu FCK, Chollet J et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature. 2004 Aug 19;430(7002):900-904. https://doi.org/10.1038/nature02779
Vennerstrom, Jonathan L. ; Arbe-Barnes, Sarah ; Brun, Reto ; Charman, Susan A. ; Chiu, Francis C.K. ; Chollet, Jacques ; Dong, Yuxiang ; Dorn, Arnulf ; Hunziker, Daniel ; Matile, Hugues ; McIntosh, Kylie ; Padmanilayam, Maniyan ; Santo Tomas, Josefina ; Scheurer, Christian ; Scorneaux, Bernard ; Tang, Yuanqing ; Urwyler, Heinrich ; Wittlin, Sergio ; Charman, William H. / Identification of an antimalarial synthetic trioxolane drug development candidate. In: Nature. 2004 ; Vol. 430, No. 7002. pp. 900-904.
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