Identification of an Anti-MRSA Cyclic Lipodepsipeptide, WBP-29479A1, by Genome Mining of Lysobacter antibioticus

Moli Sang, Haoxin Wang, Yuemao Shen, Nathalia Rodrigues De Almeida, Martin Conda-Sheridan, Shanren Li, Yaoyao Li, Liangcheng Du

Research output: Contribution to journalArticle

Abstract

Lysobacter are ubiquitous in the environment but remain largely underexplored, although the bacteria are considered "peptide specialists". Here, we identified a new cyclic lipodepsipeptide, WBP-29479A1 (1), through genome mining of L. antibioticus ATCC 29479. 1 is biosynthesized by a large NRPS gene cluster, and its structure, including the six nonproteinogenic residues and 3-hydroxy fatty acid, was determined by extensive spectroscopic analyses and chemical derivatization. 1 exhibits potent anti-MRSA activity in a menaquinone-dependent manner.

Original languageEnglish (US)
Pages (from-to)6432-6436
Number of pages5
JournalOrganic Letters
Volume21
Issue number16
DOIs
StatePublished - Aug 16 2019

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Lysobacter
Vitamin K 2
Hydroxy Acids
genome
fatty acids
Methicillin-Resistant Staphylococcus aureus
Multigene Family
genes
bacteria
peptides
Fatty Acids
Genes
Genome
Bacteria
Peptides

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Identification of an Anti-MRSA Cyclic Lipodepsipeptide, WBP-29479A1, by Genome Mining of Lysobacter antibioticus. / Sang, Moli; Wang, Haoxin; Shen, Yuemao; Rodrigues De Almeida, Nathalia; Conda-Sheridan, Martin; Li, Shanren; Li, Yaoyao; Du, Liangcheng.

In: Organic Letters, Vol. 21, No. 16, 16.08.2019, p. 6432-6436.

Research output: Contribution to journalArticle

Sang, Moli ; Wang, Haoxin ; Shen, Yuemao ; Rodrigues De Almeida, Nathalia ; Conda-Sheridan, Martin ; Li, Shanren ; Li, Yaoyao ; Du, Liangcheng. / Identification of an Anti-MRSA Cyclic Lipodepsipeptide, WBP-29479A1, by Genome Mining of Lysobacter antibioticus. In: Organic Letters. 2019 ; Vol. 21, No. 16. pp. 6432-6436.
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