Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm

Lili Guo, Deanna J. Volle, Robert E Lewis

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The kinase suppressor of Ras 2 (KSR2) is a scaffold protein for the extracellular signal-regulated protein kinase (ERK) signaling pathway. KSR2 mediates germline mpk-1 (Caenorhabditis elegans ERK) phosphorylation in C. elegans and has been implicated the regulation of meiosis. KSR2-/- mice exhibit metabolic abnormalities and are reproductively impaired. The role of KSR2 in meiosis and fertility in mice has yet to be elucidated. Here, we describe a novel truncated KSR2 mRNA identified in mouse testes (T-KSR2). Further analysis demonstrates T-KSR2 is specific to mouse testes and mature sperm cells. The detection of T-KSR2 may enhance our understanding of mechanisms controlling spermatogenesis and fertility.

Original languageEnglish (US)
Pages (from-to)420-425
Number of pages6
JournalFEBS Open Bio
Volume4
DOIs
StatePublished - Jan 1 2014

Fingerprint

Spermatozoa
Messenger RNA
Caenorhabditis elegans
Meiosis
Fertility
Testis
Phosphorylation
KSR-1 protein kinase
MAP Kinase Signaling System
Extracellular Signal-Regulated MAP Kinases
Spermatogenesis
Scaffolds
Protein Kinases
Proteins

Keywords

  • KSR2
  • Scaffold
  • Sperm

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm. / Guo, Lili; Volle, Deanna J.; Lewis, Robert E.

In: FEBS Open Bio, Vol. 4, 01.01.2014, p. 420-425.

Research output: Contribution to journalArticle

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