Abstract

OBJECTIVE: Evaluate the association between thyroid disease and use of insecticides, herbicides, and fumigants/fungicides in male applicators in the Agricultural Health Study. METHODS: We examined the association between use of 50 specific pesticides and self-reported hypothyroidism, hyperthyroidism, and "other" thyroid disease among 22,246 male pesticide applicators. RESULTS: There was increased odds of hypothyroidism with ever use of the herbicides 2,4-D (2,4-dichlorophenoxyacetic acid), 2,4,5-T (2,4,5- trichlorophenoxyacetic acid), 2,4,5-TP (2,4,5-trichlorophenoxy-propionic acid), alachlor, dicamba, and petroleum oil. Hypothyroidism was also associated with ever use of eight insecticides: organochlorines chlordane, dichlorodiphenyltrichloroethane (DDT), heptachlor, lindane, and toxaphene; organophosphates diazinon and malathion; and the carbamate carbofuran. Exposure-response analysis showed increasing odds with increasing level of exposure for the herbicides alachlor and 2,4-D and the insecticides aldrin, chlordane, DDT, lindane, and parathion. CONCLUSION: There is an association between hypothyroidism and specific herbicides and insecticides in male applicators, similar to previous results for spouses.

Original languageEnglish (US)
Pages (from-to)1171-1178
Number of pages8
JournalJournal of occupational and environmental medicine
Volume55
Issue number10
DOIs
StatePublished - Oct 1 2013

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Herbicides
Insecticides
Hypothyroidism
Pesticides
2,4-Dichlorophenoxyacetic Acid
2,4,5-Trichlorophenoxyacetic Acid
Chlordan
Lindane
Thyroid Diseases
Health
Dicamba
Toxaphene
Heptachlor
Carbofuran
Aldrin
Diazinon
Parathion
Malathion
Carbamates
Organophosphates

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Hypothyroidism and Pesticide Use among Male Private Pesticide Applicators in the Agricultural Health Study. / Goldner, Whitney S; Sandler, Dale P.; Yu, Fang; Shostrom, Valerie; Hoppin, Jane A.; Kamel, Freya; LeVan, Tricia D.

In: Journal of occupational and environmental medicine, Vol. 55, No. 10, 01.10.2013, p. 1171-1178.

Research output: Contribution to journalArticle

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AU - Yu, Fang

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AU - Kamel, Freya

AU - LeVan, Tricia D

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N2 - OBJECTIVE: Evaluate the association between thyroid disease and use of insecticides, herbicides, and fumigants/fungicides in male applicators in the Agricultural Health Study. METHODS: We examined the association between use of 50 specific pesticides and self-reported hypothyroidism, hyperthyroidism, and "other" thyroid disease among 22,246 male pesticide applicators. RESULTS: There was increased odds of hypothyroidism with ever use of the herbicides 2,4-D (2,4-dichlorophenoxyacetic acid), 2,4,5-T (2,4,5- trichlorophenoxyacetic acid), 2,4,5-TP (2,4,5-trichlorophenoxy-propionic acid), alachlor, dicamba, and petroleum oil. Hypothyroidism was also associated with ever use of eight insecticides: organochlorines chlordane, dichlorodiphenyltrichloroethane (DDT), heptachlor, lindane, and toxaphene; organophosphates diazinon and malathion; and the carbamate carbofuran. Exposure-response analysis showed increasing odds with increasing level of exposure for the herbicides alachlor and 2,4-D and the insecticides aldrin, chlordane, DDT, lindane, and parathion. CONCLUSION: There is an association between hypothyroidism and specific herbicides and insecticides in male applicators, similar to previous results for spouses.

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