Hypoplasia of the cerebellar vermis in neurogenetic syndromes

G. Bradley Schaefer, James N. Thompson, John B. Bodensteiner, James M. McConnell, William J Kimberling, Charles T. Gay, William D. Dutton, David C. Hutchings, Stanton B. Gray

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

There are conflicting reports on the relationship between cerebellar vermal lobule hypoplasia and autism. Using quantitative magnetic resonance image analysis, we measured the cerebellar vermis in 125 normal individuals with a broad age range and 102 patients with a variety of neurogenetic abnormalities. We conclude that hypoplasia of cerebellar vermal lobules VI and VII is a nonspecific finding that even occurs in several conditions without autistic behavior. This suggests that it is not a specific neuroanatomical marker for autism, nor is cerebellar dysgenesis likely to be solely responsible for clinical autistic behaviors.

Original languageEnglish (US)
Pages (from-to)382-385
Number of pages4
JournalAnnals of Neurology
Volume39
Issue number3
DOIs
StatePublished - Apr 15 1996

Fingerprint

Autistic Disorder
Magnetic Resonance Spectroscopy
Cerebellar Vermis
Cerebellar Hypoplasia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Bradley Schaefer, G., Thompson, J. N., Bodensteiner, J. B., McConnell, J. M., Kimberling, W. J., Gay, C. T., ... Gray, S. B. (1996). Hypoplasia of the cerebellar vermis in neurogenetic syndromes. Annals of Neurology, 39(3), 382-385. https://doi.org/10.1002/ana.410390316

Hypoplasia of the cerebellar vermis in neurogenetic syndromes. / Bradley Schaefer, G.; Thompson, James N.; Bodensteiner, John B.; McConnell, James M.; Kimberling, William J; Gay, Charles T.; Dutton, William D.; Hutchings, David C.; Gray, Stanton B.

In: Annals of Neurology, Vol. 39, No. 3, 15.04.1996, p. 382-385.

Research output: Contribution to journalArticle

Bradley Schaefer, G, Thompson, JN, Bodensteiner, JB, McConnell, JM, Kimberling, WJ, Gay, CT, Dutton, WD, Hutchings, DC & Gray, SB 1996, 'Hypoplasia of the cerebellar vermis in neurogenetic syndromes', Annals of Neurology, vol. 39, no. 3, pp. 382-385. https://doi.org/10.1002/ana.410390316
Bradley Schaefer G, Thompson JN, Bodensteiner JB, McConnell JM, Kimberling WJ, Gay CT et al. Hypoplasia of the cerebellar vermis in neurogenetic syndromes. Annals of Neurology. 1996 Apr 15;39(3):382-385. https://doi.org/10.1002/ana.410390316
Bradley Schaefer, G. ; Thompson, James N. ; Bodensteiner, John B. ; McConnell, James M. ; Kimberling, William J ; Gay, Charles T. ; Dutton, William D. ; Hutchings, David C. ; Gray, Stanton B. / Hypoplasia of the cerebellar vermis in neurogenetic syndromes. In: Annals of Neurology. 1996 ; Vol. 39, No. 3. pp. 382-385.
@article{a50ea0f5b7a846a3aa4912e6d39b0742,
title = "Hypoplasia of the cerebellar vermis in neurogenetic syndromes",
abstract = "There are conflicting reports on the relationship between cerebellar vermal lobule hypoplasia and autism. Using quantitative magnetic resonance image analysis, we measured the cerebellar vermis in 125 normal individuals with a broad age range and 102 patients with a variety of neurogenetic abnormalities. We conclude that hypoplasia of cerebellar vermal lobules VI and VII is a nonspecific finding that even occurs in several conditions without autistic behavior. This suggests that it is not a specific neuroanatomical marker for autism, nor is cerebellar dysgenesis likely to be solely responsible for clinical autistic behaviors.",
author = "{Bradley Schaefer}, G. and Thompson, {James N.} and Bodensteiner, {John B.} and McConnell, {James M.} and Kimberling, {William J} and Gay, {Charles T.} and Dutton, {William D.} and Hutchings, {David C.} and Gray, {Stanton B.}",
year = "1996",
month = "4",
day = "15",
doi = "10.1002/ana.410390316",
language = "English (US)",
volume = "39",
pages = "382--385",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Hypoplasia of the cerebellar vermis in neurogenetic syndromes

AU - Bradley Schaefer, G.

AU - Thompson, James N.

AU - Bodensteiner, John B.

AU - McConnell, James M.

AU - Kimberling, William J

AU - Gay, Charles T.

AU - Dutton, William D.

AU - Hutchings, David C.

AU - Gray, Stanton B.

PY - 1996/4/15

Y1 - 1996/4/15

N2 - There are conflicting reports on the relationship between cerebellar vermal lobule hypoplasia and autism. Using quantitative magnetic resonance image analysis, we measured the cerebellar vermis in 125 normal individuals with a broad age range and 102 patients with a variety of neurogenetic abnormalities. We conclude that hypoplasia of cerebellar vermal lobules VI and VII is a nonspecific finding that even occurs in several conditions without autistic behavior. This suggests that it is not a specific neuroanatomical marker for autism, nor is cerebellar dysgenesis likely to be solely responsible for clinical autistic behaviors.

AB - There are conflicting reports on the relationship between cerebellar vermal lobule hypoplasia and autism. Using quantitative magnetic resonance image analysis, we measured the cerebellar vermis in 125 normal individuals with a broad age range and 102 patients with a variety of neurogenetic abnormalities. We conclude that hypoplasia of cerebellar vermal lobules VI and VII is a nonspecific finding that even occurs in several conditions without autistic behavior. This suggests that it is not a specific neuroanatomical marker for autism, nor is cerebellar dysgenesis likely to be solely responsible for clinical autistic behaviors.

UR - http://www.scopus.com/inward/record.url?scp=9044247453&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9044247453&partnerID=8YFLogxK

U2 - 10.1002/ana.410390316

DO - 10.1002/ana.410390316

M3 - Article

VL - 39

SP - 382

EP - 385

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 3

ER -