Hypoglycaemic activity of some medicinal plants in Sri-Lanka

M. R. Fernando, M. I. Thabrew, E. H. Karunanayake

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

1. Investigations were carried out to determine whether aqueous extracts of Osbeckia octandra, Artocarpus heterophyllus and Bambusa vulgaris truly possess oral hypoglycaemic activity. 2. All three plant extracts significantly lowered the fasting blood glucose level and markedly improved glucose tolerance in Sprague-Dawley rats. 3. A maximum hypoglycaemic activity was observed at + 3 hr with O. octandra and B. vulgaris; with A. heterophyllus a maximum effect was not observed even at + 5 hr. 4. The hypoglycaemic activity of O. octandra was comparable with that of tolbutamide while that of A. heterophyllus or B. vulgaris was better than that of tolbutamide. 5. The magnitude of the hypoglycaemic effects varied with the dosage used and the time of storage (except with A. heterophyllus, whose activity did not change with storage even up to 3 days).

Original languageEnglish (US)
Pages (from-to)779-782
Number of pages4
JournalGeneral Pharmacology
Volume21
Issue number5
DOIs
StatePublished - 1990

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Sri Lanka
Medicinal Plants
Hypoglycemic Agents
Tolbutamide
Bambusa
Artocarpus
Plant Extracts
Sprague Dawley Rats
Blood Glucose
Fasting
Glucose

ASJC Scopus subject areas

  • Pharmacology

Cite this

Fernando, M. R., Thabrew, M. I., & Karunanayake, E. H. (1990). Hypoglycaemic activity of some medicinal plants in Sri-Lanka. General Pharmacology, 21(5), 779-782. https://doi.org/10.1016/0306-3623(90)91033-N

Hypoglycaemic activity of some medicinal plants in Sri-Lanka. / Fernando, M. R.; Thabrew, M. I.; Karunanayake, E. H.

In: General Pharmacology, Vol. 21, No. 5, 1990, p. 779-782.

Research output: Contribution to journalArticle

Fernando, MR, Thabrew, MI & Karunanayake, EH 1990, 'Hypoglycaemic activity of some medicinal plants in Sri-Lanka', General Pharmacology, vol. 21, no. 5, pp. 779-782. https://doi.org/10.1016/0306-3623(90)91033-N
Fernando, M. R. ; Thabrew, M. I. ; Karunanayake, E. H. / Hypoglycaemic activity of some medicinal plants in Sri-Lanka. In: General Pharmacology. 1990 ; Vol. 21, No. 5. pp. 779-782.
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