Hypertonic saline dextran produces early (8-12 hrs) fluid sparing in burn resuscitation: A 24-hr prospective, double-blind study in sheep

Geir Ivar Elgjo, Luiz F. Poli De Figueiredo, Paul J. Schenarts, Daniel L. Traber, Lillian D. Traber, George C. Kramer

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objective: Resuscitation of large bum injuries must quickly restore and maintain cardiovascular function and fluid balance while minimizing secondary edema-related damage. We tested the hypothesis that two 4-mL·kg-1 doses of hypertonic saline dextran (HSD; 7.5% NaCl/6% dextran-70) can produce prolonged reduction in fluid requirements after burn injury. Design: Prospective, pseudo randomized, double-blind study. Setting: Animal research laboratory. Subjects: Female adult Merino sheep (n = 12). Interventions: Sheep were given a 40% total body surface area full-thickness flame burn under halothane anesthesia. One hour after the burn, the conscious animals received an initial dose of 4 mL·kg-1 HSD (n = 6) or normal saline (NS; NaCl 0.9%) (n = 6) intravenously during 30 mins. This was followed by lactated Ringer's solution, infused to a target urine output of 1 mL·kg- 1·hr-1 throughout the 24-hr study. A second 4-mL·kg-1 dose of HSD or NS was started at 12 hrs, and infused during 5 hrs. Measurements and Main Results: Hourly urine output measurements were used to guide the infusion rate of the lactated Ringer's. The initial infusion of HSD 1 hr after the burn injury promptly restored cardiac index, promoted diuresis, and reduced fluid requirements compared with the NS controls (73% reduction for HSD relative to NS at 8 hrs). Subsequent rebound fluid accumulation resulted in similar net fluid balances in both groups within 12 hrs after the burn. The second dose of HSD, given at 12 hrs, was without effect on hemodynamics and fluid balance. Conclusions: We conclude a considerable initial, but not sustained fluid-sparing effect of early HSD, and no effect of a late, slowly infused HSD dose in this two-dose regimen.

Original languageEnglish (US)
Pages (from-to)163-171
Number of pages9
JournalCritical care medicine
Volume28
Issue number1
DOIs
StatePublished - Jan 1 2000

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dextran - saline drug combination
Water-Electrolyte Balance
Double-Blind Method
Resuscitation
Sheep
Wounds and Injuries
Urine
Body Surface Area
Diuresis
Halothane
Dextrans
Edema
Anesthesia
Hemodynamics
Ringer's lactate

Keywords

  • Cardiovascular function
  • Colloid
  • Crystalloid
  • Edema
  • Fluid balance
  • Lactated Ringer's
  • Parkland formula
  • Sheep
  • Shock
  • Thermal injury

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Hypertonic saline dextran produces early (8-12 hrs) fluid sparing in burn resuscitation : A 24-hr prospective, double-blind study in sheep. / Elgjo, Geir Ivar; Poli De Figueiredo, Luiz F.; Schenarts, Paul J.; Traber, Daniel L.; Traber, Lillian D.; Kramer, George C.

In: Critical care medicine, Vol. 28, No. 1, 01.01.2000, p. 163-171.

Research output: Contribution to journalArticle

Elgjo, Geir Ivar ; Poli De Figueiredo, Luiz F. ; Schenarts, Paul J. ; Traber, Daniel L. ; Traber, Lillian D. ; Kramer, George C. / Hypertonic saline dextran produces early (8-12 hrs) fluid sparing in burn resuscitation : A 24-hr prospective, double-blind study in sheep. In: Critical care medicine. 2000 ; Vol. 28, No. 1. pp. 163-171.
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AU - Elgjo, Geir Ivar

AU - Poli De Figueiredo, Luiz F.

AU - Schenarts, Paul J.

AU - Traber, Daniel L.

AU - Traber, Lillian D.

AU - Kramer, George C.

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AB - Objective: Resuscitation of large bum injuries must quickly restore and maintain cardiovascular function and fluid balance while minimizing secondary edema-related damage. We tested the hypothesis that two 4-mL·kg-1 doses of hypertonic saline dextran (HSD; 7.5% NaCl/6% dextran-70) can produce prolonged reduction in fluid requirements after burn injury. Design: Prospective, pseudo randomized, double-blind study. Setting: Animal research laboratory. Subjects: Female adult Merino sheep (n = 12). Interventions: Sheep were given a 40% total body surface area full-thickness flame burn under halothane anesthesia. One hour after the burn, the conscious animals received an initial dose of 4 mL·kg-1 HSD (n = 6) or normal saline (NS; NaCl 0.9%) (n = 6) intravenously during 30 mins. This was followed by lactated Ringer's solution, infused to a target urine output of 1 mL·kg- 1·hr-1 throughout the 24-hr study. A second 4-mL·kg-1 dose of HSD or NS was started at 12 hrs, and infused during 5 hrs. Measurements and Main Results: Hourly urine output measurements were used to guide the infusion rate of the lactated Ringer's. The initial infusion of HSD 1 hr after the burn injury promptly restored cardiac index, promoted diuresis, and reduced fluid requirements compared with the NS controls (73% reduction for HSD relative to NS at 8 hrs). Subsequent rebound fluid accumulation resulted in similar net fluid balances in both groups within 12 hrs after the burn. The second dose of HSD, given at 12 hrs, was without effect on hemodynamics and fluid balance. Conclusions: We conclude a considerable initial, but not sustained fluid-sparing effect of early HSD, and no effect of a late, slowly infused HSD dose in this two-dose regimen.

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KW - Crystalloid

KW - Edema

KW - Fluid balance

KW - Lactated Ringer's

KW - Parkland formula

KW - Sheep

KW - Shock

KW - Thermal injury

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