Hyperammonemic encephalopathy in urinary diversion with urea-splitting urinary tract infection

Francis F. Kaveggia, Jon S Thompson, Edwin C. Schafer, Jerry L. Fischer, Rodney J. Taylor

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

We present two cases of hyperammonemic encephalopathy secondary to urea-splitting urinary tract infection with urinary diversion. One patient had a ureterosigmoidostomy, the other an ileal loop diversion. Neither patient had significant underlying liver disease, but both had considerable muscle atrophy that may have predisposed them to develop hyperammonemia. Medical therapy did not provide long-term control of symptoms. In both cases, hyperammonemic encephalopathy resolved after revision of their urinary diversions. The probable mechanism of the metabolic derangements produced by urea-splitting urinary tract infections is reviewed. We suggest that patients with urinary diversion who develop hyperammonemic encephalopathy secondary to a urea-splitting urinary tract infection be treated with surgical revision of the urinary system to improve drainage and decrease bowel contact time.

Original languageEnglish (US)
Pages (from-to)2389-2392
Number of pages4
JournalArchives of Internal Medicine
Volume150
Issue number11
DOIs
StatePublished - Nov 26 1990

Fingerprint

Urinary Diversion
Brain Diseases
Urinary Tract Infections
Urea
Hyperammonemia
Muscular Atrophy
Reoperation
Liver Diseases
Drainage
Therapeutics

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Hyperammonemic encephalopathy in urinary diversion with urea-splitting urinary tract infection. / Kaveggia, Francis F.; Thompson, Jon S; Schafer, Edwin C.; Fischer, Jerry L.; Taylor, Rodney J.

In: Archives of Internal Medicine, Vol. 150, No. 11, 26.11.1990, p. 2389-2392.

Research output: Contribution to journalArticle

Kaveggia, Francis F. ; Thompson, Jon S ; Schafer, Edwin C. ; Fischer, Jerry L. ; Taylor, Rodney J. / Hyperammonemic encephalopathy in urinary diversion with urea-splitting urinary tract infection. In: Archives of Internal Medicine. 1990 ; Vol. 150, No. 11. pp. 2389-2392.
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