Hydroxyl Radical Formation in Neutrophils

Bradley E. Britigan, Myron S. Cohen, Gerald M. Rosen

Research output: Contribution to journalLetter

13 Scopus citations


To the Editor: As detailed by Malech and Gallin (Sept. 10 issue),1 much indirect evidence links neutrophil-mediated damage with hydroxyl radicals formed by the iron-catalyzed reaction between Superoxide and hydrogen peroxide (Haber–Weiss reaction). However, the mechanisms whereby neutrophil oxygen reduction could result in the formation of hydroxyl radicals in vivo are much less clear to many investigators than one might gather from Malech and Gallin's review. Implicit in the review and in many that preceded it is the tenet that a hydroxyl radical is a “physiologic” product of the neutrophil respiratory burst. This would require that the cells possess an.

Original languageEnglish (US)
Pages (from-to)858-859
Number of pages2
JournalNew England Journal of Medicine
Issue number13
Publication statusPublished - Mar 31 1988


ASJC Scopus subject areas

  • Medicine(all)

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