Hybrid Donor-Acceptor Polymer Particles with Amplified Energy Transfer for Detection and On-Demand Treatment of Breast Cancer

Elizabeth Graham-Gurysh, Sneha Kelkar, Eleanor McCabe-Lankford, Narayanan Kuthirummal, Theodore Brown, Nancy D. Kock, Aaron M Mohs, Nicole Levi-Polyachenko

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Judicious combination of semiconducting polymers with alternating electron donor (D) and acceptor (A) segments created hybrid nanoparticles with amplified energy transfer and red-shifted emission, while simultaneously providing photothermal capabilities. Hybrid D-A polymer particles (H-DAPPs) passively localized within orthotopic breast tumors, serving as bright fluorescent beacons. Laser stimulation induced heat generation on par with gold nanorods, resulting in selective destruction of the tumor. H-DAPPs can also undergo multiple thermal treatments, with no loss of fluorescence intensity or photothermal potential. These results indicate that H-DAPPs provide new avenues for the synthesis of hybrid nanoparticles useful in localized detection and treatment of disease.

Original languageEnglish (US)
Pages (from-to)7697-7703
Number of pages7
JournalACS Applied Materials and Interfaces
Volume10
Issue number9
DOIs
StatePublished - Mar 7 2018

Fingerprint

Energy transfer
Polymers
Tumors
Semiconducting polymers
Nanoparticles
Heat generation
Nanorods
Gold
Fluorescence
Heat treatment
Electrons
Lasers

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Graham-Gurysh, E., Kelkar, S., McCabe-Lankford, E., Kuthirummal, N., Brown, T., Kock, N. D., ... Levi-Polyachenko, N. (2018). Hybrid Donor-Acceptor Polymer Particles with Amplified Energy Transfer for Detection and On-Demand Treatment of Breast Cancer. ACS Applied Materials and Interfaces, 10(9), 7697-7703. https://doi.org/10.1021/acsami.7b19503

Hybrid Donor-Acceptor Polymer Particles with Amplified Energy Transfer for Detection and On-Demand Treatment of Breast Cancer. / Graham-Gurysh, Elizabeth; Kelkar, Sneha; McCabe-Lankford, Eleanor; Kuthirummal, Narayanan; Brown, Theodore; Kock, Nancy D.; Mohs, Aaron M; Levi-Polyachenko, Nicole.

In: ACS Applied Materials and Interfaces, Vol. 10, No. 9, 07.03.2018, p. 7697-7703.

Research output: Contribution to journalArticle

Graham-Gurysh, E, Kelkar, S, McCabe-Lankford, E, Kuthirummal, N, Brown, T, Kock, ND, Mohs, AM & Levi-Polyachenko, N 2018, 'Hybrid Donor-Acceptor Polymer Particles with Amplified Energy Transfer for Detection and On-Demand Treatment of Breast Cancer', ACS Applied Materials and Interfaces, vol. 10, no. 9, pp. 7697-7703. https://doi.org/10.1021/acsami.7b19503
Graham-Gurysh, Elizabeth ; Kelkar, Sneha ; McCabe-Lankford, Eleanor ; Kuthirummal, Narayanan ; Brown, Theodore ; Kock, Nancy D. ; Mohs, Aaron M ; Levi-Polyachenko, Nicole. / Hybrid Donor-Acceptor Polymer Particles with Amplified Energy Transfer for Detection and On-Demand Treatment of Breast Cancer. In: ACS Applied Materials and Interfaces. 2018 ; Vol. 10, No. 9. pp. 7697-7703.
@article{5b1df222fc7a454bad80855d6b630dae,
title = "Hybrid Donor-Acceptor Polymer Particles with Amplified Energy Transfer for Detection and On-Demand Treatment of Breast Cancer",
abstract = "Judicious combination of semiconducting polymers with alternating electron donor (D) and acceptor (A) segments created hybrid nanoparticles with amplified energy transfer and red-shifted emission, while simultaneously providing photothermal capabilities. Hybrid D-A polymer particles (H-DAPPs) passively localized within orthotopic breast tumors, serving as bright fluorescent beacons. Laser stimulation induced heat generation on par with gold nanorods, resulting in selective destruction of the tumor. H-DAPPs can also undergo multiple thermal treatments, with no loss of fluorescence intensity or photothermal potential. These results indicate that H-DAPPs provide new avenues for the synthesis of hybrid nanoparticles useful in localized detection and treatment of disease.",
author = "Elizabeth Graham-Gurysh and Sneha Kelkar and Eleanor McCabe-Lankford and Narayanan Kuthirummal and Theodore Brown and Kock, {Nancy D.} and Mohs, {Aaron M} and Nicole Levi-Polyachenko",
year = "2018",
month = "3",
day = "7",
doi = "10.1021/acsami.7b19503",
language = "English (US)",
volume = "10",
pages = "7697--7703",
journal = "ACS applied materials & interfaces",
issn = "1944-8244",
publisher = "American Chemical Society",
number = "9",

}

TY - JOUR

T1 - Hybrid Donor-Acceptor Polymer Particles with Amplified Energy Transfer for Detection and On-Demand Treatment of Breast Cancer

AU - Graham-Gurysh, Elizabeth

AU - Kelkar, Sneha

AU - McCabe-Lankford, Eleanor

AU - Kuthirummal, Narayanan

AU - Brown, Theodore

AU - Kock, Nancy D.

AU - Mohs, Aaron M

AU - Levi-Polyachenko, Nicole

PY - 2018/3/7

Y1 - 2018/3/7

N2 - Judicious combination of semiconducting polymers with alternating electron donor (D) and acceptor (A) segments created hybrid nanoparticles with amplified energy transfer and red-shifted emission, while simultaneously providing photothermal capabilities. Hybrid D-A polymer particles (H-DAPPs) passively localized within orthotopic breast tumors, serving as bright fluorescent beacons. Laser stimulation induced heat generation on par with gold nanorods, resulting in selective destruction of the tumor. H-DAPPs can also undergo multiple thermal treatments, with no loss of fluorescence intensity or photothermal potential. These results indicate that H-DAPPs provide new avenues for the synthesis of hybrid nanoparticles useful in localized detection and treatment of disease.

AB - Judicious combination of semiconducting polymers with alternating electron donor (D) and acceptor (A) segments created hybrid nanoparticles with amplified energy transfer and red-shifted emission, while simultaneously providing photothermal capabilities. Hybrid D-A polymer particles (H-DAPPs) passively localized within orthotopic breast tumors, serving as bright fluorescent beacons. Laser stimulation induced heat generation on par with gold nanorods, resulting in selective destruction of the tumor. H-DAPPs can also undergo multiple thermal treatments, with no loss of fluorescence intensity or photothermal potential. These results indicate that H-DAPPs provide new avenues for the synthesis of hybrid nanoparticles useful in localized detection and treatment of disease.

UR - http://www.scopus.com/inward/record.url?scp=85043342816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043342816&partnerID=8YFLogxK

U2 - 10.1021/acsami.7b19503

DO - 10.1021/acsami.7b19503

M3 - Article

C2 - 29457709

AN - SCOPUS:85043342816

VL - 10

SP - 7697

EP - 7703

JO - ACS applied materials & interfaces

JF - ACS applied materials & interfaces

SN - 1944-8244

IS - 9

ER -