Hyaluronan Synthesis and Turnover in Prostate Cancer

Melanie A. Simpson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Several genetic susceptibility loci have been identified that may account for higher risk through reduced ability to cope with environmental insults. Tumors detected early are often managed effectively by surgical resection and/or hormone ablation therapy. However, a significant percentage of tumors will resume growth in the absence of androgens. This chapter provides an understanding of the transformation from androgen dependent to androgen independent prostate cancer. It also discusses the clinical correlation and functional roles of hyaluronan (HA) synthases, hyaluronidases, and HA receptors in specific aspects of prostate cancer. Relatively few genetic determinants of prostate cancer have been identified and the well documented role of inflammation in prostate carcinogenesis is addressed. Synthesis and deposition of HA is normally associated with cell division, motility, transformation, and vascular development in embryogenesis. Many studies have demonstrated the strong correlation between HA accumulation and malignancy in solid tumors. HA production in cultured tumor cells is significantly stimulated by growth factors and proinflammatory cytokines are known to be elevated in human prostate cancer specimens. Various studies suggest an important link between clinically relevant tumor proliferation signals and inappropriate HA biosynthesis.

Original languageEnglish (US)
Title of host publicationHyaluronan in Cancer Biology
PublisherElsevier Inc.
Pages309-327
Number of pages19
ISBN (Print)9780123741783
DOIs
StatePublished - Dec 1 2009

Fingerprint

Hyaluronic Acid
Tumors
Prostatic Neoplasms
Androgens
Neoplasms
Cells
CD44 Antigens
Cultured Tumor Cells
Genetic Loci
Hyaluronoglucosaminidase
Biosynthesis
Genetic Predisposition to Disease
Ablation
Cell Division
Embryonic Development
Cell Movement
Blood Vessels
Prostate
Intercellular Signaling Peptides and Proteins
Carcinogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Simpson, M. A. (2009). Hyaluronan Synthesis and Turnover in Prostate Cancer. In Hyaluronan in Cancer Biology (pp. 309-327). Elsevier Inc.. https://doi.org/10.1016/B978-012374178-3.10016-X

Hyaluronan Synthesis and Turnover in Prostate Cancer. / Simpson, Melanie A.

Hyaluronan in Cancer Biology. Elsevier Inc., 2009. p. 309-327.

Research output: Chapter in Book/Report/Conference proceedingChapter

Simpson, MA 2009, Hyaluronan Synthesis and Turnover in Prostate Cancer. in Hyaluronan in Cancer Biology. Elsevier Inc., pp. 309-327. https://doi.org/10.1016/B978-012374178-3.10016-X
Simpson MA. Hyaluronan Synthesis and Turnover in Prostate Cancer. In Hyaluronan in Cancer Biology. Elsevier Inc. 2009. p. 309-327 https://doi.org/10.1016/B978-012374178-3.10016-X
Simpson, Melanie A. / Hyaluronan Synthesis and Turnover in Prostate Cancer. Hyaluronan in Cancer Biology. Elsevier Inc., 2009. pp. 309-327
@inbook{c3c8da6a82714b9e927faf950db8f20a,
title = "Hyaluronan Synthesis and Turnover in Prostate Cancer",
abstract = "Several genetic susceptibility loci have been identified that may account for higher risk through reduced ability to cope with environmental insults. Tumors detected early are often managed effectively by surgical resection and/or hormone ablation therapy. However, a significant percentage of tumors will resume growth in the absence of androgens. This chapter provides an understanding of the transformation from androgen dependent to androgen independent prostate cancer. It also discusses the clinical correlation and functional roles of hyaluronan (HA) synthases, hyaluronidases, and HA receptors in specific aspects of prostate cancer. Relatively few genetic determinants of prostate cancer have been identified and the well documented role of inflammation in prostate carcinogenesis is addressed. Synthesis and deposition of HA is normally associated with cell division, motility, transformation, and vascular development in embryogenesis. Many studies have demonstrated the strong correlation between HA accumulation and malignancy in solid tumors. HA production in cultured tumor cells is significantly stimulated by growth factors and proinflammatory cytokines are known to be elevated in human prostate cancer specimens. Various studies suggest an important link between clinically relevant tumor proliferation signals and inappropriate HA biosynthesis.",
author = "Simpson, {Melanie A.}",
year = "2009",
month = "12",
day = "1",
doi = "10.1016/B978-012374178-3.10016-X",
language = "English (US)",
isbn = "9780123741783",
pages = "309--327",
booktitle = "Hyaluronan in Cancer Biology",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Hyaluronan Synthesis and Turnover in Prostate Cancer

AU - Simpson, Melanie A.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Several genetic susceptibility loci have been identified that may account for higher risk through reduced ability to cope with environmental insults. Tumors detected early are often managed effectively by surgical resection and/or hormone ablation therapy. However, a significant percentage of tumors will resume growth in the absence of androgens. This chapter provides an understanding of the transformation from androgen dependent to androgen independent prostate cancer. It also discusses the clinical correlation and functional roles of hyaluronan (HA) synthases, hyaluronidases, and HA receptors in specific aspects of prostate cancer. Relatively few genetic determinants of prostate cancer have been identified and the well documented role of inflammation in prostate carcinogenesis is addressed. Synthesis and deposition of HA is normally associated with cell division, motility, transformation, and vascular development in embryogenesis. Many studies have demonstrated the strong correlation between HA accumulation and malignancy in solid tumors. HA production in cultured tumor cells is significantly stimulated by growth factors and proinflammatory cytokines are known to be elevated in human prostate cancer specimens. Various studies suggest an important link between clinically relevant tumor proliferation signals and inappropriate HA biosynthesis.

AB - Several genetic susceptibility loci have been identified that may account for higher risk through reduced ability to cope with environmental insults. Tumors detected early are often managed effectively by surgical resection and/or hormone ablation therapy. However, a significant percentage of tumors will resume growth in the absence of androgens. This chapter provides an understanding of the transformation from androgen dependent to androgen independent prostate cancer. It also discusses the clinical correlation and functional roles of hyaluronan (HA) synthases, hyaluronidases, and HA receptors in specific aspects of prostate cancer. Relatively few genetic determinants of prostate cancer have been identified and the well documented role of inflammation in prostate carcinogenesis is addressed. Synthesis and deposition of HA is normally associated with cell division, motility, transformation, and vascular development in embryogenesis. Many studies have demonstrated the strong correlation between HA accumulation and malignancy in solid tumors. HA production in cultured tumor cells is significantly stimulated by growth factors and proinflammatory cytokines are known to be elevated in human prostate cancer specimens. Various studies suggest an important link between clinically relevant tumor proliferation signals and inappropriate HA biosynthesis.

UR - http://www.scopus.com/inward/record.url?scp=84882554351&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882554351&partnerID=8YFLogxK

U2 - 10.1016/B978-012374178-3.10016-X

DO - 10.1016/B978-012374178-3.10016-X

M3 - Chapter

AN - SCOPUS:84882554351

SN - 9780123741783

SP - 309

EP - 327

BT - Hyaluronan in Cancer Biology

PB - Elsevier Inc.

ER -